胞外囊泡及其促进胰腺癌侵袭转移的机制

doi:10.3760/cma.j.issn.1673422X.2016.12.017

摘要/Abstract

摘要： 胞外囊泡（EV）由原核生物及真核生物所分泌，广泛存在于血液、尿液、腹腔积液、胆汁等各种体液及肿瘤微环境中。EV在细胞生长、运动、信号传导以及肿瘤细胞的侵袭转移中发挥重要作用。胰腺癌恶性程度高，侵袭转移能力强，EV可通过促进细胞增殖、抑制免疫反应、促进血管形成和基质重塑等机制促进胰腺癌的侵袭转移。

关键词: 胰腺肿瘤, 肿瘤侵润, 肿瘤转移, 胞外囊泡

Abstract: The secretion of extracellular vesicles (EVs) is a wellconserved evolutionary process that occurs from prokaryotic cells to eukaryotes. EVs have been identified in body fluids such as plasma, urine, ascites, and bile as well as tumor microenvironment. EVs play an important role in cell growth, movement, signal transduction, invasion and metastasis of tumor cells. With a high invasive ability, pancreatic cancer has a high degree of malignancy. Evs can enhance the invasion and metastasis of pancreatic cancer by increasing cell proliferation, inhibiting immune responses, promoting angiogenesis and extracellular matrix remodeling.

Key words: Pancreatic neoplasms, Neoplasm invasiveness, Neoplasm metastasis, Extracellular vesicles

刘保瑞, 吴永娜, 周文策. 胞外囊泡及其促进胰腺癌侵袭转移的机制[J]. 国际肿瘤学杂志, 2016, 43(12): 947-949.

LIU Bao-Rui, WU Yong-Na, ZHOU Wen-Ce. Extracellular vesicles in promoting the invasion and metastasis of pancreatic cancer[J]. Journal of International Oncology, 2016, 43(12): 947-949.

参考文献

［1］ Raimondo S, Corrado C, Raimondi L, et al. Role of extracellular vesicles in hematological malignancies［J］. Biomed Res Int, 2015, 2015: 821613. DOI: 10.1155/2015/821613. ［2］ Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends［J］. J Cell Biol, 2013, 200(4): 373383. DOI: 10.1083/jcb.201211138. ［3］ Soung YH, Nguyen T, Cao H, et al. Emerging roles of exosomes in cancer invasion and metastasis［J］. BMB Rep, 2016, 49(1): 1825. DOI: 10.5483/BMBRep.2016.49.1.239. ［4］ Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles［J］. Trends Cell Biol, 2015, 25(6): 364372. DOI: 10.1016/j.tcb.2015.01.004. ［5］ Gyrgy B, Szabó TG, Pásztói M, et al. Membrane vesicles, current stateoftheart: emerging role of extracellular vesicles［J］. Cell Mol Life Sci, 2011, 68(16): 26672688. DOI: 10.1007/s0001801106893. ［6］ Green TM, Alpaugh ML, Barsky SH, et al. Breast cancerderived extracellular vesicles: characterization and contribution to the metastatic phenotype［J］. Biomed Res Int, 2015, 2015: 634865. DOI: 10.1155/2015/634865. ［7］ MomenHeravi F, Balaj L, Alian S, et al. Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles［J］. Front Physiol, 2012, 3: 162. DOI: 10.3389/fphys.2012.00162. ［8］ Kahlert C, Melo SA, Protopopov A, et al. Identification of doublestranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer［J］. J Biol Chem, 2014, 289(7): 38693875. DOI: 10.1074/jbc.C113.532267. ［9］ Subra C, Grand D, Laulagnier K, et al. Exosomes account for vesiclemediated transcellular transport of activatable phospholipases and prostaglandins［J］. J Lipid Res, 2010, 51(8): 21052120. DOI: 10.1194/jlr.M003657. ［10］ Anastasiadou E, Slack FJ. Malicious exosomes［J］. Science, 2014, 346(6216): 14591460. DOI: 10.1126/science.aaa4024. ［11］ Taylor DD, GercelTaylor C. MicroRNA signatures of tumorderived exosomes as diagnostic biomarkers of ovarian cancer［J］. Gynecol Oncol, 2008, 110(1): 1321. DOI: 10.1016/j. ［12］ Gai C, Carpanetto A, Deregibus MC, et al. Extracellular vesiclemediated modulation of angiogenesis［J］. Histol Histopathol, 2016, 31(4): 379391. DOI: 10.14670/HH11708. ［13］ Webber J, Steadman R, Mason MD, et al. Cancer exosomes trigger fibroblast to myofibroblastdifferentiation［J］. Cancer Res, 2010, 70(23): 96219630. DOI: 10.1158/00085472.CAN101722. ［14］ Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis［J］. Cancer Res, 2011, 71(11): 37923801. DOI: 10.1158/00085472.CAN104455. ［15］ Adamczyk KA, KleinScory S, Tehrani MM, et al. Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells［J］. Life Sci, 2011, 89(9/10): 304312. DOI: 10.1016/j.lfs.2011.06.020. ［16］ Shin SJ, Smith JA, Rezniczek GA, et al. Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer［J］. Proc Natl Acad Sci USA, 2013, 110(48): 1941419419. DOI: 10.1073/pnas.1309720110. ［17］ Greening DW, Gopal SK, Mathias RA, et al. Emerging roles of exosomes during epithelialmesenchymal transition and cancer progression［J］. Semin Cell Dev Biol, 2015, 40(40): 6071. DOI: 10.1016/j.semcdb.2015.02.008. ［18］ Ma C, Nong K, Wu B, et al. miR212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched1［J］. J Exp Clin Cancer Res, 2014, 33: 54. DOI: 10.1186/175699663354. ［19］ Que R, Ding G, Chen J, et al. Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma［J］. World J Surg Oncol, 2013, 11: 219. DOI: 10.1186/1477781911219. ［20］ De Jong OG, Van Balkom BW, Schiffelers RM, et al. Extracellular vesicles: potential roles in regenerative medicine［J］. Front Immunol, 2014, 5: 608. DOI: 10.3389/fimmu.2014.00608. ［21］ Zhao H, Wang Q, Wang X, et al. Correlation between RAB27B and p53 expression and overall survival in pancreatic cancer［J］. Pancreas, 2016, 45(2): 204210. DOI: 10.1097/MPA.0000000000000453.

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