国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (10): 748-751.doi: 0.3760/cma.j.issn.1673-422X.2016.10.007

• 论著 • 上一篇    下一篇

榄香烯对复发性卵巢癌腹腔积液患者疗效及生命质量的影响

王子熹   

  1. 266500 青岛市黄岛区中医医院肿瘤科
  • 出版日期:2016-10-08 发布日期:2016-09-07
  • 通讯作者: 王子熹 E-mail: wangzixi201602@163.com

Influence of elemene on curative effect and life quality for patients with recurrent ovarian cancer with ascites

Wang Zixi   

  1. Department of Oncology, Huangdao District Hospital of Traditional Chinese Medicine of Qingdao, Qingdao 266500, China
  • Online:2016-10-08 Published:2016-09-07
  • Contact: Wang Zixi E-mail: wangzixi201602@163.com

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摘要： 目的探讨榄香烯对复发性卵巢癌伴腹腔积液患者的治疗效果及其对化疗后生命质量的影响。方法选择2013年8月—2015年7月青岛市黄岛区中医医院收治的上皮性卵巢癌术后复发伴腹腔积液患者64例，采用随机数字表法将其分为对照组（n=32）和观察组（n=32），观察组应用榄香烯联合顺铂腹腔灌注化疗，对照组应用顺铂腹腔灌注化疗。比较两组间治疗效果及患者生命质量的差异。结果对照组完全缓解（CR）10例，部分缓解（PR）13例，病情稳定（SD）6例，疾病进展（PD）3例，总有效率（ORR）为71.88%；观察组CR 19例，PR 9例，SD 3例，PD 1例，ORR为87.50%，两组疗效差异有统计学意义（Z=-2.312，P=0.021）。观察组与对照组化疗后躯体功能（61.66±9.27∶51.66±15.73；t=-3.102，P=0.003）、角色功能（59.89±13.29∶45.83±19.40；t=-3.383，P=0.001）、情绪功能（49.73±11.29∶30.72±13.45；t=-6.120，P=0.000）、认知功能（62.50±13.39∶50.00±19.40；t=-3.000，P=0.004）、总健康状况（54.69±10.99∶42.97±14.98；t=-3.568，P=0.001）、疲倦症状（38.53±13.23∶47.57±19.39；t=2.175，P=0.033）、恶心呕吐症状（19.27±4.77∶36.45±12.29；t=5.483，P=0.000）及失眠症状（23.95±10.77∶38.54±11.46；t=2.216，P=0.030）的评分差异具有统计学意义。观察组与对照组化疗后社会功能（37.50±17.96∶36.97±16.79；t=-0.120，P=0.905）、疼痛症状（23.43±9.58∶22.92±9.19；t=-0.118，P=0.906）、呼吸困难症状（19.79±6.49∶16.67±5.74；t=-0.606，P=0.547）、食欲减退症状（63.54±25.90∶66.67±18.93；t=0.551，P=0.584）、便秘症状（27.08±10.59∶23.96±9.14；t=-0.545，P=0.588）、腹泻症状（63.54±25.90∶66.67±18.93；t=0.551，P=0.584）及经济困难（60.41±21.03∶65.62±29.91；t=0.683，P=0.497）的评分差异无统计学意义。结论榄香烯联合顺铂腹腔灌注化疗对于复发性卵巢癌伴腹腔积液患者有更好的疗效，并且有可能进一步改善患者的生命质量，值得深入研究和推广应用。

关键词: 卵巢肿瘤, 治疗结果, 生命质量, 榄香稀

Abstract: ObjectiveTo explore the effect of elemene on recurrent ovarian cancer with ascites and the impact on the life quality. MethodsFrom August 2013 to July 2015, 64 patients with recurrent ovarian cancer with ascites in Huangdao District Hospital of Traditional Chinese Medicine of Qingdao were collected. They were divided into control group (n=32) and observation group (n=32) by random number table. Patients in observation group were treated with elemene and cisplatin by intraperitoneal perfusion, and patients in control group were treated with cisplatin alone. The effects and life quality were compared between the two groups. ResultsThere were 10 cases of complete response (CR), 13 cases of partial response (PR), 6 cases of stable disease (SD), 3 cases of progressive disease (PD), 71.88% of overall response rate (ORR) in the control group; and there were 19 cases of CR, 9 cases of PR, 3 cases of SD, 1 case of PD, 87.50% of ORR in the observation group, with significant difference (Z=-2.312, P=0.021). There were significant differences about the physical function (61.66±9.27 vs. 51.66±15.73; t=-3.102, P=0.003), role function (59.89±13.29 vs. 45.83±19.40; t=-3.383, P=0.001), emotional function (49.73±11.29 vs. 30.72±13.45; t=-6.120, P=0.000), cognitive function (62.50±13.39 vs. 50.00±19.40; t=-3.000, P=0.004), total health status (54.69±10.99 vs. 42.97±14.98; t=-3.568, P=0.001), symptoms of fatigue (38.53±13.23 vs. 47.57±19.39; t=2.175, P=0.033), nausea and vomiting scores (19.27±4.77 vs. 36.45±12.29; t=5.483, P=0.000) and symptoms of insomnia (23.95±10.77 vs. 38.54±11.46; t=2.216, P=0.030) between the observation and control groups. There were no differences about the social function (37.50±17.96 vs. 36.97±16.79; t=-0.120, P=0.905), symptoms of pain (23.43±9.58 vs. 22.92±9.19; t=-0.118, P=0.906), difficult breathing (19.79±6.49 vs. 16.67±5.74; t=-0.606, P=0.547), anorexia (63.54±25.90 vs. 66.67±18.93; t=0.551, P=0.584), constipation (27.08±10.59 vs. 23.96±9.14; t=-0.545, P=0.588), diarrhea (63.54±25.90 vs. 66.67±18.93; t=0.551, P=0.584) and economic hardship (60.41±21.03 vs. 65.62±29.91; t=0.683, P=0.497) between the observation and control groups. ConclusionElemene combined with cisplatin achieves the better efficacy on recurrent ovarian cancer with ascites by intraperitoneal perfusion, which has the potential to further improve the patient′s life quality, and deserves to be studied and promoted application.

Key words: Ovarian neoplasms, Treatment outcome, Quality of life, Elemene