国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (10): 744-747.doi: 10.3760/cma.j.issn.1673-422X.2016.10.006

• 论著 • 上一篇    下一篇

IMP3在放化疗前后宫颈鳞状细胞癌的表达及临床意义

聂佳,吴宁,章丽霞,黄一凡,刘钧   

  1. 618000 四川省德阳市人民医院病理科（聂佳、吴宁）；川北医学院病理教研室（聂佳、黄一凡、刘钧），法医系（章丽霞）
  • 出版日期:2016-10-08 发布日期:2016-09-07
  • 通讯作者: 刘钧 E-mail:nclj02@163.com
  • 基金资助:

    四川省教育厅基金（12ZB225）

Expressions of IMP3 in cervical squamous cell carcinoma before and after the therapy of radiation and chemotherapy

Nie Jia, Wu Ning, Zhang Lixia, Huang Yifan, Liu Jun   

  1. Department of Pathology, Deyang People′s Hospital of Sichuan Province; Department of Pathology, North Sichuan Medical College, Deyang 618000, China
  • Online:2016-10-08 Published:2016-09-07
  • Contact: Liu Jun E-mail:nclj02@163.com
  • Supported by:

    Foundation of Sichuan Educational Committee (12ZB225)

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摘要： 目的探讨胰岛素样生长因子ⅡmRNA结合蛋白3（IMP3）在不同级别宫颈上皮内病变(SIL)及放化疗前后宫颈鳞状细胞癌（CSCC）组织中的表达及临床病理意义。方法采用免疫组织化学法检测IMP3蛋白在80例CSCC组织、90例SIL（60例高级别、30例低级别）以及30例宫颈炎组织中的表达情况，分析IMP3表达与CSCC临床病理特征的关系。结果IMP3在CSCC组织、高级别SIL、低级别SIL、宫颈炎组织中的表达率分别为86.3%（69/80）、78.3%（47/60）、33.3%（10/30）、0（0/30），4组间差异有统计学意义(χ2=87.01，P＜0.01)。放化疗后IMP3的表达率较放化疗前降低，差异具有统计学意义(60.0%∶85.0%；χ2=5.79，P=0.013)。IMP3的表达与淋巴结转移（χ2=3.97，P=0.046）、分化程度（χ2=5.95，P=0.018）、临床分期（χ2=5.82，P=0.016）、浸润深度（χ2=5.73，P=0.017）相关，而与患病年龄无关(χ2=0.11，P=0.745)。结论IMP3在CSCC组织中高表达，并与癌组织分化程度及浸润进展相关，放化疗可降低其表达。

关键词: 宫颈肿瘤, 宫颈上皮内瘤样病变, 免疫组织化学, 放射疗法, 药物疗法, 胰岛素样生长因子ⅡmRNA结合蛋白3

Abstract: ObjectiveTo discuss the expressions and clinicopathologic significances of insulinlike growth factor Ⅱ mRNA binding protein 3 (IMP3) in squamous intraepithelial lesion (SIL) and cervical squamous cell carcinoma (CSCC) before and after the therapy of radiation and chemotherapy. MethodsThe expressions of IMP3 in 80 cases of CSCC, 90 cases of SIL (60 cases of HSIL, 30 cases of LSIL) and 30 cases of cervicitis were detected by immunobistochemistry. The relations between IMP3 and clinicopathological characteristics of CSCC were analyzed. ResultsThe expression rates of IMP3 in CSCC, HSIL, LSIL and cervicitis were 86.3%(69/80), 78.3%(47/60), 33.3%(10/30) and 0(0/30), and the difference among the four groups was statistically signicant (χ2=87.01, P＜0.01). The positive expression rate of IMP3 declined by radiation or chemotherapy (60.0% vs. 85.0%, χ2=5.79, P=0.013). The expression of IMP3 was related with lymph node metastasis (χ2=3.97, P=0.046), differentiated degree (χ2=5.95, P=0.018), clinical stage (χ2=5.82, P=0.016) and invasion depth (χ2=5.73, P=0.017). There was nothing to do with age (χ2=0.11, P=0.745). ConclusionIMP3 expresses excessively in CSCC, and is associated with pathological grade and invasion progress. Radiochemotherapy can reduce the expression of IMP3.

Key words: Uterine cervical neoplasms, Cervical intraepithelial neoplasia, Immunohistochemistry, Radiotherapy, Drug therapy, Insulinlike growth factor Ⅱ mRNA binding protein 3