肝转移对肺癌免疫治疗疗效影响的研究进展

doi:10.3760/cma.j.cn371439-20260108-00107

摘要/Abstract

摘要：

肺癌是全球发病率和死亡率位居前列的恶性肿瘤之一，肝脏是其常见的远处转移部位，与患者不良预后密切相关。近年来，免疫检查点抑制剂（ICI）在晚期肺癌患者治疗中取得了突破性进展，肝转移患者亦可从ICI治疗中获益，但相较于整体人群，肝转移仍然是免疫治疗疗效差的独立预后因素。基于近年来的研究，将肝转移对肺癌免疫治疗疗效的影响、潜在机制以及未来研究方向等方面进行归纳总结，可为制定伴肝转移肺癌患者的综合治疗策略提供一定的参考依据。

关键词: 肺肿瘤, 肿瘤转移, 免疫疗法, 肿瘤微环境

Abstract:

Lung cancer ranks among the top malignancies in terms of both incidence and mortality rates. The liver is a common site of distant metastasis， which is closely associated with the poor prognosis. In recent years， immune checkpoint inhibitors （ICIs） have achieved significant breakthroughs in the treatment of advanced lung cancer. Patients with liver metastasis can also benefit from ICI therapy. However， compared to the overall population， the presence of liver metastasis remains an independent prognostic factor for poor efficacy of immunotherapy. Based on recent research， summarizing the impact of liver metastasis on the efficacy of immunotherapy for lung cancer， the underlying mechanisms， and future research directions may provide certain reference basis for formulating comprehensive treatment strategies for lung cancer patients with liver metastasis.

Key words: Lung neoplasms, Neoplasm metastasis, Immunotherapy, Tumor microenvironment

罗良雪, 赵朝芬, 苏胜发. 肝转移对肺癌免疫治疗疗效影响的研究进展[J]. 国际肿瘤学杂志, 2026, 53(11): 688-693.

Luo Liangxue, Zhao Chaofen, Su Shengfa. Research progress on the impact of liver metastasis on the efficacy of immunotherapy for lung cancer[J]. Journal of International Oncology, 2026, 53(11): 688-693.

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