lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制

doi:10.3760/cma.j.cn371439-20220104-00032

国际肿瘤学杂志 ›› 2022, Vol. 49 ›› Issue (3): 185-189.doi: 10.3760/cma.j.cn371439-20220104-00032

lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制

张俊鹏^1,², 于燕燕³, 李宝生²()

¹山东第一医科大学(山东省医学科学院)研究生院,济南 250117
²山东第一医科大学(山东省医学科学院) 山东省肿瘤防治研究院(山东省肿瘤医院)放疗科,济南 250117
³山东第一医科大学第一附属医院(山东省千佛山医院)神经内科,济南 250013

收稿日期:2022-01-04 修回日期:2022-01-12 出版日期:2022-03-08 发布日期:2022-03-22
通讯作者: 李宝生 E-mail:bsli@sdfmu.edu.cn
基金资助:
国家自然科学基金(81530060)

Mechanism of lncRNA and circRNA regulating the sensitivity of radiotherapy and chemotherapy in esophageal squamous cell carcinoma

Zhang Junpeng^1,², Yu Yanyan³, Li Baosheng²()

¹School of Graduate, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
²Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
³Department of Neurology, First Affiliated Hospital of Shandong First Medical University, Shandong Province Qianfoshan Hospital, Jinan 250013, China

Received:2022-01-04 Revised:2022-01-12 Online:2022-03-08 Published:2022-03-22
Contact: Li Baosheng E-mail:bsli@sdfmu.edu.cn
Supported by:
National Natural Science Foundation of China(81530060)

摘要/Abstract

摘要：

长非编码RNA(lncRNA)和环状RNA(circRNA)是两类重要的非编码RNA,可通过与DNA、RNA或蛋白质相互作用调控基因表达。lncRNA、circRNA不仅能够预测食管鳞状细胞癌(ESCC)患者的放化疗预后情况,还可以通过竞争性内源RNA机制、调控PI3K/Akt/mTOR及Wnt/β-catenin信号通路、参与DNA及蛋白质修饰、调节细胞周期等多种途径影响ESCC放化疗敏感性。对lncRNA、circRNA调控ESCC放化疗敏感性的作用机制进行深入研究,将有助于指导筛选患者人群,提高ESCC患者放化疗效果。

关键词: 食管肿瘤, 癌,鳞状细胞, 放射疗法, 化学疗法, 长链非编码RNA, 环状RNA

Abstract:

Long non-coding RNA (lncRNA) and circular RNA (circRNA) are two important types of non-coding RNA that can regulate gene expression by directly interacting with DNA, RNA or protein. A large number of studies have shown that lncRNA and circRNA can not only predict the prognosis of patients with esophageal squamous cell carcinoma (ESCC) after radiotherapy and chemotherapy, but also affect the sensitivity of ESCC to radiotherapy and chemotherapy through competing endogenous RNA mechanisms, regulating PI3K/Akt/mTOR and Wnt/β-catenin signaling pathways, participating in DNA and protein modification, regulating the cell cycle and other pathways. In-depth research on the mechanism of lncRNA and circRNA regulating the sensitivity of ESCC to radiotherapy and chemotherapy will improve the effect of radiotherapy and chemotherapy in ESCC patients.

Key words: Esophageal neoplasms, Carcinoma,squamous cell, Radiotherapy, Chemotherapy, Long non-coding RNA, Circular RNA

张俊鹏, 于燕燕, 李宝生. lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制[J]. 国际肿瘤学杂志, 2022, 49(3): 185-189.

Zhang Junpeng, Yu Yanyan, Li Baosheng. Mechanism of lncRNA and circRNA regulating the sensitivity of radiotherapy and chemotherapy in esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2022, 49(3): 185-189.

参考文献 34

[1]	He Z, Ke Y. Precision screening for esophageal squamous cell carcinoma in China[J]. Chin J Cancer Res, 2020, 32(6):673-682. DOI: 10.21147/j.issn.1000-9604.2020.06.01. doi: 10.21147/j.issn.1000-9604.2020.06.01
[2]	中国医师协会放射肿瘤治疗医师分会; 中华医学会放射肿瘤治疗学分会; 中国抗癌协会肿瘤放射治疗专业委员会. 中国食管癌放射治疗指南(2020年版)[J]. 国际肿瘤学杂志, 2020, 47(11):641-655. DOI: 10.3760/cma.j.cn371439-20201015-00095. doi: 10.3760/cma.j.cn371439-20201015-00095
[3]	Ding M, Zhang E, He R, et al. Newly developed strategies for improving sensitivity to radiation by targeting signal pathways in cancer therapy[J]. Cancer Sci, 2013, 104(11):1401-1410. DOI: 10.1111/cas.12252. doi: 10.1111/cas.12252
[4]	Yu J, Xu QG, Wang ZG, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma[J]. J Hepatol, 2018, 68(6):1214-1227. DOI: 10.1016/j.jhep.2018.01.012. doi: 10.1016/j.jhep.2018.01.012
[5]	Ma J, Xiao Y, Tian B, et al. Long noncoding RNA lnc-ABCA12-3 promotes cell migration, invasion, and proliferation by regulating fibronectin 1 in esophageal squamous cell carcinoma[J]. J Cell Biochem, 2020, 121(2):1374-1387. DOI: 10.1002/jcb.29373. doi: 10.1002/jcb.29373
[6]	Tong YS, Zhou XL, Wang XW, et al. Association of decreased expression of long non-coding RNA LOC285194 with chemoradiotherapy resistance and poor prognosis in esophageal squamous cell carcinoma[J]. J Transl Med, 2014, 12:233. DOI: 10.1186/s12967-014-0233-y. doi: 10.1186/s12967-014-0233-y
[7]	Zhou XL, Wang WW, Zhu WG, et al. High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy[J]. Mol Carcinog, 2016, 55(12):2095-2105. DOI: 10.1002/mc.22454. doi: 10.1002/mc.22454
[8]	Li ZY, Li HF, Zhang YY, et al. Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy[J]. World J Gastroenterol, 2020, 26(15):1775-1791. DOI: 10.3748/wjg.v26.i15.1775. doi: 10.3748/wjg.v26.i15.1775
[9]	Wang J, Chen Y, Wu R, et al. Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p/fermitin family members 1 axis in esophageal cancer[J]. Anticancer Drugs, 2021, 32(4):405-416. DOI: 10.1097/CAD.000000-0000001007. doi: 10.1097/CAD.000000-0000001007
[10]	Qu F, Wang L, Wang C, et al. Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis[J]. Cancer Cell Int, 2021, 21(1):273. DOI: 10.1186/s12935-021-01984-y. doi: 10.1186/s12935-021-01984-y
[11]	Lin J, Liu Z, Liao S, et al. Elevation of long non-coding RNA GAS5 and knockdown of microRNA-21 up-regulate RECK expression to enhance esophageal squamous cell carcinoma cell radio-sensitivity after radiotherapy[J]. Genomics, 2020, 112(3):2173-2185. DOI: 10.1016/j.ygeno.2019.12.013. doi: 10.1016/j.ygeno.2019.12.013
[12]	Liu J, Zhou R, Deng M, et al. Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9[J]. Cancer Gene Ther, 2021, In press. DOI: 10.1038/s41417-021-00344-2. doi: 10.1038/s41417-021-00344-2
[13]	Wang L, Wang X, Yan P, et al. LINC00261 suppresses cisplatin resistance of esophageal squamous cell carcinoma through miR-545-3p/MT1M axis[J]. Front Cell Dev Biol, 2021, 9:687788. DOI: 10.3389/fcell.2021.687788. doi: 10.3389/fcell.2021.687788
[14]	Chen X, Wang W, Li Y, et al. MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling[J]. J Exp Clin Cancer Res, 2021, 40(1):341. DOI: 10.1186/s13046-021-02106-2. doi: 10.1186/s13046-021-02106-2
[15]	Liu G, Guo W, Chen G, et al. Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2[J]. Int J Biol Sci, 2020, 16(15):2938-2950. DOI: 10.7150/ijbs.47051. doi: 10.7150/ijbs.47051
[16]	Liu H, Zhang J, Luo X, et al. Overexpression of the long noncoding RNA FOXD2-AS1 promotes cisplatin resistance in esophageal squamous cell carcinoma through the miR-195/Akt/mTOR axis[J]. Oncol Res, 2020, 28(1):65-73. DOI: 10.3727/096504019-X15656904013079. doi: 10.3727/096504019-X15656904013079
[17]	Chen M, Liu P, Chen Y, et al. Long noncoding RNA FAM201A mediates the radiosensitivity of esophageal squamous cell cancer by regulating ATM and mTOR expression via miR-101[J]. Front Genet, 2018, 9:611. DOI: 10.3389/fgene.2018.00611. doi: 10.3389/fgene.2018.00611
[18]	Wang M, Wang L, He X, et al. lncRNA CCAT2 promotes radiotherapy resistance for human esophageal carcinoma cells via the miR-145/p70S6K1 and p53 pathway[J]. Int J Oncol, 2020, 56(1):327-336. DOI: 10.3892/ijo.2019.4929. doi: 10.3892/ijo.2019.4929
[19]	Wang P, Yang Z, Ye T, et al. lncTUG1/miR-144-3p affect the radiosensitivity of esophageal squamous cell carcinoma by competitively regulating c-MET[J]. J Exp Clin Cancer Res, 2020, 39(1):7. DOI: 10.1186/s13046-019-1519-y. doi: 10.1186/s13046-019-1519-y
[20]	He Y, Mingyan E, Wang C, et al. CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway[J]. Int J Biol Macromol, 2019, 125:116-123. DOI: 10.1016/j.ijbiomac.2018.11.273. doi: 10.1016/j.ijbiomac.2018.11.273
[21]	Zhang S, Jiang H, Xu Z, et al. The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long nonco-ding RNA DDX11-AS1 through TAF1/TOP2A inhibition[J]. Am J Cancer Res, 2019, 9(10):2233-2248.
[22]	Zou FW, Yang SZ, Li WY, et al. CircRNA_001275 upregulates Wnt7a expression by competitively sponging miR-370-3p to promote cisplatin resistance in esophageal cancer[J]. Int J Oncol, 2020, 57(1):151-160. DOI: 10.3892/ijo.2020.5050. doi: 10.3892/ijo.2020.5050
[23]	Liu J, Xue N, Guo Y, et al. CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway[J]. Aging (Albany NY), 2019, 11(24):12412-12427. DOI: 10.18632/aging.102580. doi: 10.18632/aging.102580
[24]	Li N, Zhao Z, Miao F, et al. Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation[J]. Cancer Gene Ther, 2021, 28(5):471-485. DOI: 10.1038/s41417-020-00232-1. doi: 10.1038/s41417-020-00232-1
[25]	Chen JL, Lin ZX, Qin YS, et al. Overexpression of long noncoding RNA LINC01419 in esophageal squamous cell carcinoma and its relation to the sensitivity to 5-fluorouracil by mediating GSTP1 methy-lation[J]. Ther Adv Med Oncol, 2019, 11:1758835919838958. DOI: 10.1177/1758835919838958. doi: 10.1177/1758835919838958
[26]	Zhang S, Zheng F, Zhang L, et al. LncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells[J]. J Exp Clin Cancer Res, 2020, 39(1):131. DOI: 10.1186/s13046-020-01610-1. doi: 10.1186/s13046-020-01610-1
[27]	Lin K, Jiang H, Zhuang SS, et al. Long noncoding RNA LINC00261 induces chemosensitization to 5-fluorouracil by mediating methylation-dependent repression of DPYD in human esophageal cancer[J]. FASEB J, 2019, 33(2):1972-1988. DOI: 10.1096/fj.201800759R. doi: 10.1096/fj.201800759R
[28]	Zhang S, Liao W, Wu Q, et al. LINC00152 upregulates ZEB1 expression and enhances epithelial-mesenchymal transition and oxaliplatin resistance in esophageal cancer by interacting with EZH2[J]. Cancer Cell Int, 2020, 20(1):569. DOI: 10.1186/s12935-020-01620-1. doi: 10.1186/s12935-020-01620-1
[29]	Liu Z, Gu S, Wu K, et al. CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation[J]. J Exp Clin Cancer Res, 2021, 40(1):361. DOI: 10.1186/s13046-021-02149-5. doi: 10.1186/s13046-021-02149-5
[30]	Liu Z, Lu X, Wen L, et al. Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p/CDC25A axis[J]. Anticancer Drugs, 2022, 33(1):e349-e361. DOI: 10.1097/CAD.0000000000001213. doi: 10.1097/CAD.0000000000001213
[31]	Liu WH, Qiao HY, Xu J, et al. LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA-497-5p and cell division cycle 25A[J]. Int J Mol Med, 2020, 46(2):571-582. DOI: 10.3892/ijmm.2020.4616. doi: 10.3892/ijmm.2020.4616
[32]	Li YJ, Lei YH, Yao N, et al. Autophagy and multidrug resistance in cancer[J]. Chin J Cancer, 2017, 36(1):52. DOI: 10.1186/s40880-017-0219-2. doi: 10.1186/s40880-017-0219-2
[33]	Zhu ZJ, Pang Y, Jin G, et al. Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis[J]. Aging (Albany NY), 2021, 13(13):17155-17176. DOI: 10.18632/aging.203062. doi: 10.18632/aging.203062
[34]	Tong Y, Yang L, Yu C, et al. Tumor-secreted exosomal lncRNA POU3F3 promotes cisplatin resistance in ESCC by inducing fibroblast differentiation into CAFs[J]. Mol Ther Oncolytics, 2020, 18:1-13. DOI: 10.1016/j.omto.2020.05.014. doi: 10.1016/j.omto.2020.05.014

lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制

Mechanism of lncRNA and circRNA regulating the sensitivity of radiotherapy and chemotherapy in esophageal squamous cell carcinoma

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 34

相关文章 15

编辑推荐

Metrics

本文评价

[1]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊. 局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[2]	高凡, 王萍, 杜超, 褚衍六. 肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[3]	刘静, 刘芹, 黄梅. 基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[4]	万芳, 杨钢, 李睿, 万启晶. 食管癌患者血清miR-497、miR-383水平及临床意义[J]. 国际肿瘤学杂志, 2024, 51(4): 204-209.
[5]	李书月, 马辰莺, 周菊英, 徐晓婷, 秦颂兵. 寡转移非小细胞肺癌的放疗进展[J]. 国际肿瘤学杂志, 2024, 51(3): 170-174.
[6]	李济时, 陆钊群, 刘俊茹, 吕建勋, 陈霜, 沈琳, 徐志渊, 吴平安. 新辅助放疗联合部分喉切除术治疗喉滑膜肉瘤1例并文献复习[J]. 国际肿瘤学杂志, 2024, 51(2): 123-125.
[7]	中国医师协会放射肿瘤治疗医师分会, 中华医学会放射肿瘤治疗学分会, 中国抗癌协会肿瘤放射治疗专业委员会. 中国食管癌放射治疗指南（2023年版）[J]. 国际肿瘤学杂志, 2024, 51(1): 1-20.
[8]	高新雨, 李振江, 孙洪福, 韩丹, 赵倩, 刘成新, 黄伟. 基于MR加速器的MR引导放疗在食管癌患者中的临床应用[J]. 国际肿瘤学杂志, 2024, 51(1): 37-42.
[9]	崔腾璐, 吕璐, 孙鹏飞. 放疗联合免疫治疗在头颈部鳞状细胞癌治疗中的应用[J]. 国际肿瘤学杂志, 2023, 50(9): 548-552.
[10]	山东省医学会肺癌食管癌多学科联合委员会. 山东省医学会食管癌多学科规范化诊疗指南（2023年版）[J]. 国际肿瘤学杂志, 2023, 50(7): 385-397.
[11]	李青珊, 谢鑫, 张楠, 刘帅. 放疗联合系统治疗在乳腺癌中的应用进展[J]. 国际肿瘤学杂志, 2023, 50(6): 362-367.
[12]	许萌, 姜伟, 朱海涛, 曹雄锋. 癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 227-230.
[13]	石小琪, 汪红艳. 肠道菌群与放射性肠炎的相互作用及研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 244-247.
[14]	冀世玉, 张明鑫, 谢华红, 白渊, 王彤. 不同支架治疗晚期食管癌患者的疗效观察[J]. 国际肿瘤学杂志, 2023, 50(2): 76-81.
[15]	巩合义, 伊艳, 张健, 李宝生. 局部晚期可手术食管癌经新辅助放化疗达临床完全缓解后的处理策略[J]. 国际肿瘤学杂志, 2023, 50(12): 745-750.