铁死亡在白血病治疗中的研究进展

doi:10.3760/cma.j.cn371439-20220816-00149

摘要/Abstract

摘要：

白血病是一类血液系统恶性肿瘤。铁死亡是一种铁依赖的脂质过氧化积累介导的新型细胞死亡方式，其参与白血病的发生发展，激活铁死亡通路中不同的调节位点可促进白血病细胞的死亡。通过诱导细胞发生铁死亡的方式达到治疗白血病的目的，为白血病的治疗研究提供新的方向。

关键词: 白血病, 铁死亡, 治疗学

Abstract:

Leukemia is a group of hematologic malignancie. Ferroptosis is a novel of cell death caused by iron-dependent lipid peroxidation accumulation, which participates in the occurrence and development of leukemia. Activation of different regulatory sites in the ferroptosis pathway can promote the death of leukemia cells. Therefore, it can provide a new direction for the treatment of leukemia by inducing ferroptosis of cells.

Key words: Leukemia, Ferroptosis, Therapeutics

周欣宇, 贾秀红. 铁死亡在白血病治疗中的研究进展[J]. 国际肿瘤学杂志, 2022, 49(12): 759-762.

Zhou Xinyu, Jia Xiuhong. Research progress of ferroptosis in the treatment of leukemia[J]. Journal of International Oncology, 2022, 49(12): 759-762.

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