国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (3): 180-183.doi: 10.3760/cma.j.cn371439-20200629-00036

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PARP抑制剂治疗铂耐药卵巢癌的研究进展

李晨曦1, 赵宏伟2,*()   

  1. 1山西医科大学第二临床医学院,太原 030001
    2山西省肿瘤医院妇二科,太原 030001
  • 收稿日期:2020-06-29 修回日期:2020-07-26 出版日期:2021-03-08 发布日期:2021-03-25
  • 通讯作者: 赵宏伟 E-mail:inmind20060829@126.com
  • 基金资助:
    CSCO-恒瑞肿瘤研究基金(Y-HR2018-330);山西省重点研发计划(201903D321174)

Advances in the treatment of platinum-resistant ovarian cancer with PARP inhibitors

Li Chenxi1, Zhao Hongwei2,*()   

  1. 1Second Clinical College, Shanxi Medical University, Taiyuan 030001, China
    2Second Department of Gynecology, Shanxi Provincial Cancer Hospital, Taiyuan 030001, China
  • Received:2020-06-29 Revised:2020-07-26 Online:2021-03-08 Published:2021-03-25
  • Contact: Zhao Hongwei E-mail:inmind20060829@126.com
  • Supported by:
    CSCO-Hengrui Cancer Research Fund(Y-HR2018-330);Key Research and Development Program of Shanxi Province of China(201903D321174)

摘要:

聚ADP核糖聚合酶(PARP)抑制剂是一种治疗卵巢癌的靶向生物制剂,其适用人群主要是对铂治疗敏感的卵巢癌患者。但有临床试验数据表明PARP抑制剂对铂耐药或铂难治卵巢癌患者也有一定治疗效果,未来可能成为卵巢癌患者治疗的新希望。

关键词: 卵巢肿瘤, 聚核糖聚合酶聚ADP核糖聚合酶类, 化疗

Abstract:

Poly ADP-ribose polymerase(PARP)inhibitor is a targeted biological agent for the treatment of ovarian cancer, which is mainly suitable for platinum-sensitive ovarian cancer patients. However, data from clinical trials showed that PARP inhibitors have certain therapeutic effect on platinum-resistant or platinum-refractory ovarian cancer patients. It may become a new hope for treatment of ovarian cancer patients in the future.

Key words: Ovarian neoplasms, Poly(ADP-ribose) polymerase, Chemotherapy