国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (5): 376-379.doi: 10.3760/cma.j.issn.1673422X.2017.05.013

• 综述 • 上一篇    下一篇

手术与肿瘤转移

徐芳明, 张勇, 许建华, 孙珏, 朱秋梅, 李悦   

  1. 200333上海市普陀区中心医院中医肿瘤科
  • 出版日期:2017-05-08 发布日期:2017-04-19
  • 通讯作者: 张勇，Email: zhangyong75@msn.com E-mail:zhangyong75@msn.com
  • 基金资助:

    国家自然科学基金（81273733）

Operation and tumor metastasis

Xu Fangming, Zhang Yong, Xu Jianhua, Sun Jue, Zhu Qiumei, Li Yue   

  1. Oncology Department of Traditional Chinese Medicine, Putuo District Central Hospital of Shanghai, Shanghai 200333, China
  • Online:2017-05-08 Published:2017-04-19
  • Contact: Zhang Yong E-mail:zhangyong75@msn.com
  • Supported by:

    National Natural Science Foundation of China (81273733)

PDF

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摘要： 在形成新的转移灶之前，原发肿瘤释放的大量癌细胞会进入一个休眠阶段，休眠状态一旦被打破，肿瘤细胞将恢复增殖能力。近年来关于肿瘤转移的各种假说和机制研究层出不穷，原发瘤切除术被看作是打破肿瘤休眠稳态的一个重要因素，因而被认为是促进肿瘤转移的重要原因。手术技术的改良和对休眠机制的进一步研究，可以为转移瘤的治疗提供新的思路。

关键词: 肿瘤转移, 外科手术, 休眠期

Abstract: Prior to the formation of new metastases, a large number of cancer cells released from the primary tumor enter the dormancy period. Once the dormancy is broken, tumor cells will recover the capability of proliferation. In recent years, various hypotheses and mechanisms of tumor metastasis have been studied. Primary tumor resection is considered to be an important factor to break tumor dormancy state. It is recognized as an important reason to promote tumor metastasis. The improvement of surgical technique and further study on the mechanism of dormancy may provide new ideas for the treatment of metastatic tumor.

Key words: Neoplasm metastasis, Surgery procedures, operative, Dormancy period