国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 937-939.doi: 10.3760/cma.j.issn.1673-422X.2017.12.014

• 综述 • 上一篇    下一篇

长非编码RNA在胃癌中的研究进展

张国华,张文波,蒋鹏程   

  1. 212002 镇江，江苏大学附属人民医院普外科
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 张文波，Email： wb.zhan@hotmail.com E-mail:wb.zhan@hotmail.com
  • 基金资助:
    国家自然科学基金(81500193)；中国博士后科学基金(2015M571703)；江苏省自然科学基金(BK20161353)

Research progress of long noncoding RNA in gastric cancer

Zhang Guohua, Zhang Wenbo, Jiang Pengcheng   

  1. Department of General Surgery, Affiliated People′s Hospital of Jiangsu University, Zhenjiang 212002, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Zhang Wenbo, Email: wb.zhan@hotmail.com E-mail:wb.zhan@hotmail.com
  • Supported by:
    National Natural Science Foundation of China (81500193); China Postdoctoral Science Foundation (2015M571703); Natural Science Foundation of Jiangsu Province of China (BK20161353)

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摘要： 长非编码RNA (lncRNA)可通过表观遗传调控、可变剪接及竞争性内源性RNA机制广泛参与胃癌的发生、增殖、侵袭转移、凋亡、血管生成、免疫和耐药等生物学过程。此外，lncRNA在胃癌诊断、靶向治疗和预后等方面具有广阔前景。

关键词: 胃肿瘤, 肿瘤转移, 长非编码RNA

Abstract: Long noncoding RNA (lncRNA) can extensively participate in the pathogenesis, proliferation, invasion and metastasis, apoptosis, angiogenesis, immunization, and drug resistance of gastric cancer through various mechanisms, including epigenetic regulation, variable splicing and competitive endogenous RNA. In addition, lncRNA has broad prospects in the diagnosis, targeted therapy and prognosis of gastric cancer.

Key words: Stomach neoplasms, Neoplasm metastasis, Long noncoding RNA