国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 926-928.doi: 10.3760/cma.j.issn.1673-422X.2017.12.011

• 综述 • 上一篇    下一篇

钠钾氯共转运体1与胶质瘤

马海文,于圣平,杨学军   

  1. 300052, 天津医科大学总医院神经外科
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 杨学军，Email: ydenny@126.com E-mail:ydenny@126.com
  • 基金资助:
    国家自然科学基金（81472352、81502171）

Na+-K+-2Cl- cotransporter 1 and glioma

Ma Haiwen, Yu Shengping, Yang Xuejun.   

  1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Yang Xuejun, Email: ydenny@126.com E-mail:ydenny@126.com
  • Supported by:
    National Natural Science Foundation of China (81472352, 81502171)

PDF

557

摘要： 钠钾氯共转运体1（NKCC1）在恶性胶质瘤中高表达，其与胶质瘤的恶性程度密切相关。NKCC1蛋白在胶质瘤细胞的体积调节方面起重要作用，NKCC1蛋白使胶质瘤细胞自如地变换体积，穿过狭窄的细胞外间隙向远处迁移播散；NKCC1与肿瘤细胞骨架调节也有密切关系。此外，NKCC1亦与细胞周期、神经能活性等其他生物功能密切相关。总之，NKCC1在胶质瘤中扮演了重要的角色。

关键词: 神经胶质瘤, 钠钾氯共转运体1

Abstract: Na+-K+-2Cl- cotransporter 1 (NKCC1) is highly expressed in malignant gliomas, which is closely related to the degree of malignancy. NKCC1 protein has a vital function in the volume regulation of glioma cells. NKCC1 allows glioma cells to transform its volume freely, migrating through the narrow extracellular space to achieve distant metastases. There is also close relationship between NKCC1 and tumor cytoskeleton regulation. In addition, NKCC1 is closely associated with cell cycle, nerve activity and other biological functions. In conclusion, NKCC1 plays an important role in gliomas.

Key words: Glioma, Na+-K+-2Cl- cotransporter 1