国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (3): 165-168.doi: 10.3760/cma.j.issn.1673422X.2015.03.002

• 论著 • 上一篇    下一篇

胶质瘤瘤周水肿、病理级别、Ki67表达三者相关性研究

洪宇, 郑勇, 吴永刚, 张诚, 王继超   

  1. 832003 石河子大学医学院神经外科（洪宇）；新疆自治区人民医院神经外科（郑勇、吴永刚、张诚、王继超）
  • 出版日期:2015-03-08 发布日期:2015-01-29
  • 通讯作者: 郑勇，Email： xjzy3682@126.com E-mail:Zheng Yong, Email: xjzy3682@126.com
  • 基金资助:

    新疆维吾尔自治区自然科学基金（2012211A087）

Correlational study of peritumoral brain edema, histological grades and the expression of Ki67 in gliomas

 Hong-Yu, ZHENG  Yong, WU  Yong-Gang, ZHANG  Cheng, WANG  Ji-Chao   

  1. Department of Neurosurger, Shihezi University of Medicine, Shihezi 832003, China
  • Online:2015-03-08 Published:2015-01-29
  • Contact: Zheng Yong E-mail:Zheng Yong, Email: xjzy3682@126.com

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摘要： 目的探讨胶质瘤患者瘤周水肿（PTBE）程度、肿瘤病理级别、Ki67阳性表达率三者之间的相关性。方法收集新疆自治区人民医院神经外科2010—2013年经手术切除，病理证实的胶质瘤患者病历资料及标本74例，根据术前磁共振成像（MRI）资料判断肿瘤PTBE程度，免疫组织化学检测Ki67表达情况，HE染色区别肿瘤病理级别。结果本组研究中90.54%（67/74）伴发PTBE，其中Ⅰ、Ⅱ、Ⅲ、Ⅳ级别组PTBE发生率各为100%（3/3）、78.95%（15/19）、83.33%（15/18）及100%（34/34）；75.68%（56/74）Ki67表达呈阳性；Ⅰ、Ⅱ、Ⅲ、Ⅳ级别组阳性率分别为0、36.84%（7/19）、94.44%(17/18)、94.12%(32/34)；无水肿、Ⅰ度水肿与Ⅱ水肿组中Ki67表达阳性率分别为57.14%（4/7）、60.00%(6/10)、80.70%(46/57)。经KruskalWallis H检验，PTBE在不同级别胶质瘤的总体差异有统计学意义（H=11.304，P=0.010）；Ki67在不同级别胶质瘤中总体差异有统计学意义（H=38.530，P＜0.05）；Ki67在不同PTBE组中表达的总体差异有统计学意义（H=6.478，P=0.039）。Spearman等级相关分析显示胶质瘤PTBE程度随肿瘤病理级别增加而增加(r=0.385,P=0.001）；Ki67表达阳性率随肿瘤病理级别增加而增加（r=0.692，P＜0.05）；Ki67表达阳性率随胶质瘤PTBE增加而增加（r=0.256，P=0.028）。结论术前根据PTBE的大小可预测肿瘤的恶性程度与增殖活性，Ki67既可作为肿瘤增殖活性的指标，也可当做病理分级的重要依据。

关键词: 神经胶质瘤, 瘤周水肿, 病理级别, Ki67

Abstract: ObjectiveTo explore the correlation of peritumoral brain edema (PTBE) size, histological grades and the expression rate of Ki67 in gliomas. MethodsThe data and specimens about 74 cases of gliomas in People's Hospital of Xinjiang Uygur Autonomous Region during 20102013 were collected. All cases were confirmed by surgery and pathology. According to preoperative MRI, PTBE was graded. Immunohistochemical discriminate the expression of Ki67. HE coloration distinguish the histological grades.ResultsIn this study, 90.54% (67/74) patients occured PTBE, the incidence of PTBE inⅠ, Ⅱ, Ⅲ, Ⅳ level of groups were 100%(3/3), 78.95% (15/19), 83.33% (15/18), 100% (34/34). Ki67 expression was positive in 75.68% (56/74) patients, and the rates were 0, 36.84% (7/19), 94.44% (17/18), 94.12% (32/34) in Ⅰ, Ⅱ, Ⅲ, Ⅳ level of groups. The expression rate of Ki67 was 57.14% (4/7), 60.00% (6/10), and 80.70% (46/57) in  normal group, Ⅰlevel groups of PTBE, Ⅱlevel groups of PTBE. The result of KruskalWallis H showed that  the PTBE from different grades was statistically significant (H=11.304, P=0.010). The expression rate of Ki67 in different grade gliomas was statistically significant (H=38.530, P＜0.05), The difference of expression Ki67 in gliomas of different PTBE was statistically significant (H=6.478, P=0.039). The result of Spearman rank correlation analysis showed that the PTBE level increased with the histological grade up in gliomas (r=0.385, P=0.001). The expression rate of Ki67 increased with the histological grade up in gliomas (r=0.692, P＜0.05), and the expression rate of Ki67 increased with the degree of  PTBE up in glomas (r=0.256, P=0.028).ConclusionAccorrding to the PTBE size, the histological grades and proliferation ability of glioma can be judged preoperation. Ki67 can be used as the indicator of proliferation activity of tumor, and also be used as the important basis of histological grades.

Key words: Glioma, Peritumoral edema, Pathological grade, Ki67 antigen