国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (8): 579-582.doi: 10.3760/cma.j.issn.1673-422X.2014.08.007

• 综述 • 上一篇    下一篇

胶质瘤钙离子通道研究进展

刘洋,汪延明   

  1. 250031济南军区总医院放疗科
  • 收稿日期:2014-02-24 修回日期:2014-03-25 出版日期:2014-08-15 发布日期:2014-08-14
  • 通讯作者: 汪延明,E-mail:ymwang64@163.com E-mail:ymwang64@163.com

Calcium channels in glioma

Liu Yang, Wamg Yanming   

  1. Department of Radiation Oncology, Ji′nan Military General Hospital, Ji′nan 250031, China
  • Received:2014-02-24 Revised:2014-03-25 Online:2014-08-15 Published:2014-08-14
  • Contact: Wamg Yanming E-mail:ymwang64@163.com

摘要: 钙离子通道在神经胶质瘤中异常表达,并且在胶质瘤的发生、增殖、转移、肿瘤血管生成等方面起关键性作用。研究发现,不同类型钙通道表达升高或下降能够影响胶质瘤的生长发展及其细胞周期的再分布,提示其可能成为胶质瘤治疗的新靶点,为控制胶质瘤的进展提供新的思路。

关键词: 神经胶质瘤, 钙通道, 钙通道阻滞药

Abstract: Calcium channels express abnormally in glioma, and play a key role in the physiological functions of glioma such as tumorigenesis, proliferation, metastasis and angiogenesis. Researches show that low or high expressions of different types of calcium channels have influence on the development of glioma and cellcycle redistribution. Such calcium channels may represent new targets in treating glioma,which provide new ideas for controlling glioma.

Key words: Glioma, Calcium channels, Calcium channel blockers