国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 481-484.doi: 10.3760/cma.j.issn.1673422X.2014.07.001

• 综述 •    下一篇

转录因子KLF9与肿瘤的研究进展

申彭亮,施国伟   

  1. 200240 复旦大学附属上海市第五人民医院泌尿外科
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 施国伟， Email：dr.sgw@189.cn E-mail:dr.sgw@189.cn
  • 基金资助:

    上海市医学重点专科基金（ZK2012A22）

Research progress in association between the Kruppellike factor 9 and tumor development

 SHEN  Peng-Liang, SHI  Guo-Wei   

  1.  Department of Urology, Fifth People′s Hospital of Shanghai, Fudan University, Shanghai 200240, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Shi Guowei E-mail:dr.sgw@189.cn

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被引次数

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摘要： Kruppel样因子9（KLF9）是参与基因转录调控的锌指蛋白之一，广泛参与了细胞的增殖、分化以及组织器官的分化发育等过程。KLF9在多种肿瘤组织及肿瘤细胞中低表达，对肿瘤细胞的增殖及凋亡发挥重要作用。KLF9可以通过多种信号途径以及与细胞内不同蛋白的相互作用，影响肿瘤细胞的增殖及凋亡，影响肿瘤的形成和发展，在内分泌相关肿瘤方面KLF9的作用尤为明显。

关键词: 肿瘤形成过程, 基因表达, 细胞凋亡, Kruppel样转录因子类

Abstract: KLF9 (Kruppellike factor 9) is the transcription factor that can bind GCrich sites through three C2H2type zinc fingers and can regulate diverse biological processes, including cell proliferation, apoptosis and the development of the organ. KLF9 is downregulated in some tumor specimens and tumorous cell lines relative to the normal samples and cell lines and plays an important role in the growth of cancer cells. Similar with the other KLF numbers, KLF9 could affect the development of tumors, especially for the endocrinerelated cancers through multiple signaling pathways and interventions with other proteins.

Key words: Neoplastic processes, Gene expression, Cell apoptosis, Kruppellike transcription factors