国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 552-556.

• 论著 • 上一篇    下一篇

血管生成素-2在肝细胞癌组织中的表达及其与预后的关系

关铁军, 杨玉波, 王斌, 陈峰, 刘峰, 王晓明, 华南, 周平, 闫光志, 吕牮, 王帅, 郝彦勇   

  1. 130012 长春，吉林省肿瘤医院腹部肿瘤外科（关铁军、杨玉波、王斌、陈峰、刘峰、王晓明、华南、周平、闫光志、吕牮），病理科（王帅、郝彦勇）
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 杨玉波，E-mail：yuboyangcn@yahoo.com.cn E-mail:yuboyangcn@yahoo.com.cn
  • 基金资助:

    吉林省自然科学基金（201215217）；吉林省发改委产业技术研究与开发项目（JF2012C006-6），吉林省发改委高技术产业发展项目（JF2012C012）

Expression of angiopoietin-2 and prognosis after hepatic resection in hepatocellular carcinoma

GUAN  Tie-Jun, YANG  Yu-Bo, WANG  Bin, CHEN  Feng, LIU  Feng, WANG  Xiao-Ming, HUA  Nan, ZHOU  Ping, YAN  Guang-Zhi, LU Jian , WANG  Shuai, HAO  Yan-Yong-   

  1. Department of Abdominal Oncologic Surgery, Jilin Cancer Hospital, Changchun 130012, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: YANG Yu-Bo E-mail:yuboyangcn@yahoo.com.cn

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摘要： 目的 研究血管生成素-2(Ang-2)在肝细胞癌（HCC）组织中表达及其在判断预后中的价值。方法 对随访的60例原发性肝癌临床资料进行回顾性分析，通过免疫组化方法检测Ang-2在癌组织中的表达情况。研究其与病理因子、组织学分化程度的相关性，并分析Ang-2表达与生存期的关系。结果 Ang-2表达率为70%；Ang-2表达与病理因子无关（P＞0.05），与组织学分化程度相关（X2=5.424，P=0.025）；Ang-2高表达中低分化比例高（66.7%）。高表达组和低表达组患者的1、3、5年无瘤生存率分别为50.0%、33.3%、16.7%和89.6%、50.0%、27.1%。高表达患者无瘤生存期明显低于低表达患者（X2=6.477，P＝0.021）。结论 Ang-2表达多寡与HCC组织分化程度相关，与病理因子无关；Ang-2高表达者生存期低。Ang-2是肝癌切除术后判定预后的预测因子。

关键词: 血管生成素2, 癌, 肝细胞, 免疫组织化学

Abstract: Objective  To study the relationship between the expressions of angiopoietins-2 (Ang-2) and prognosis in hepatocellular carcinoma (HCC) after hepatic resection. Methods  Sixty patients with primary liver cancer were retrospectively analyzed and the expressions of Ang-2 in carcinoma tissues were assayed by immunohistochemical staining. The interrelationships among the expressions of Ang-2, clinicopathological factors and the grade of differentiation of HCC cells were studied. The relationship between the expressions of Ang-2 and survival time was analysed. Results  The expression rate of Ang-2 was 70%. Ang-2 staining had no correlation with clinicopathological factors (P＞0.05), but it had a significant correlation with the grade of differentiation of HCC cells (χ2=5.424，P=0.025). Ang-2 of moderately and poorly differentiated HCC were higher (66.7%) than those of well-differentiated HCC. The disease-free survival rates of patients with high Ang-2 expression and low Ang-2 expression were 50% (1-year), 33.3% (3-year), 16.7% (5-year) and 89.6% (1-year), 50.0% (3-year), 27.1% (5-year), respectively. The disease-free survival of patients with high Ang-2 expression were significantly less than those of patients with low Ang-2 expression (χ2=6.477, P =0.021). Conclusion  The expressions of Ang-2 are correlated with the grade of differentiation of HCC cells, but are not correlate with clinicopathological factors. The survivals of patients with Ang-2 high expression are lower than those of low expression. Ang-2 is a significant predictive factor for recurrence after hepatic resection in HCC patients.

Key words: Angiopoietin-2, Carcinoma, hepatocellular, Immunohistochemistry