国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 536-539.

• 综述 • 上一篇    下一篇

微小RNA与肾癌

马旭怡, 徐海燕, 何小舟, 张学光   

  1. 213003 常州，苏州大学附属第三医院 常州市第一人民医院泌尿外科（马旭怡、徐海燕、何小舟），苏州大学医学生物技术研究所（张学光）
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 徐海燕，E-mail: xuhaiyan09@163.com E-mail:xuhaiyan09@163.com

MicroRNA and renal carcinoma

MA  Xu-Yi, XU  Hai-Yan, HE  Xiao-Zhou, ZHANG  Xue-Guang   

  1. Department of Urinary Surgery, Third Affiliated Hospital of Soochow University, Changzhou 213003, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: XU Hai-Yan E-mail:xuhaiyan09@163.com

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摘要： 微小RNA（miRNA）是进化保守的非编码RNA分子，通过与靶mRNA的3,-非编码区互补结合介导基因的转录后调控，参与调节个体发育、细胞分裂、分化、凋亡、脂肪代谢等多种生物进程。miRNA参与包括肾癌在内的多种肿瘤的发生发展,在肾癌的发生发展过程中通过调控其靶基因参与的信号通路，发挥着类似于癌基因或抑癌基因的功能。

关键词: 微RNAs, 肾肿瘤, 癌基因, 基因, 肿瘤抑制

Abstract: MicroRNAs (miRNAs) are evolutionary conserved non-coding RNA molecules. They involve in a variety of biological processes such as regulating the individual development, cell division, differentiation, apoptotic and fat metabolism through post-transcription pathway. It has been shown that miRNAs play important roles in the development and progression of many tumors, including of renal carcinoma. MiRNAs play functions similar to oncogenes or anti-oncogenes in the development and progression of renal carcinoma by regulating the signaling pathway of its target genes involving in.

Key words: MicroRNAs, Kidney neoplasms, Oncogenes, Genes, tumor suppressor