国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 348-350.

• 综述 • 上一篇    下一篇

微小RNA与鼻咽癌

程荫, 李晓江   

  1. 650118昆明医科大学第三附属医院 云南省肿瘤医院头颈外科
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 基金资助:

    云南省卫生科技计划项目（2010NS085）

MicroRNAand nasopharyngeal carcinoma

CHENG  Yin, LI  Xiao-Jiang   

  1. Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancerr Hospital, Kunming 650000, China
  • Online:2013-05-08 Published:2013-05-15

PDF

1563

被引次数

5

摘要： 微小RNA（miRNA）是在真核生物中发现的一类内源性的具有调控功能的非编码RNA，其大小长约20~25个核苷酸。最新研究发现，miRNA与鼻咽癌中Epstein-Barr病毒（EBV）、潜在的膜蛋白（LMP-1）、信号转导通路、肿瘤相关基因网络、细胞有丝分裂、肿瘤血管生成和侵袭转移密切相关。探索miRNA与鼻咽癌发生发展之间的关系，有助于加深对其发病机制的认识，也将为临床诊断和治疗提供新的启示与依据。

关键词: 鼻咽肿瘤, 微RNAs

Abstract: MicroRNA (miRNA) is a class of endogenous non-coding RNA which found in eukaryotes and has regulatory function. Its size is about 20 to 25 nucleotides. Recent study found that miRNA is closly related to the EBV, LMP1, signal transduction pathway, tumor-associated gene network, cell mitosis, tumor angiogenesis, tumor invasion and metastasis of nasopharyngeal. Therefore, studing the relationship between miRNA and nasopharyngeal will help to deepen the understanding of its pathogenesis, and also will provide new inspiration and basis for clinical diagnosis and treatment.

Key words: Nasopharyngeal neoplasms, MicroRNAs