国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 236-238.

• 论著 • 上一篇    下一篇

SIRT1和p53在合并糖尿病子宫内膜癌的表达及意义

郭宏英, 郭淑芹, 程晓东, 赵文明, 李志红, 杨茜   

  1. 071000  保定第一中心医院内分泌科( 郭宏英、郭淑芹、程晓东、李志红、杨茜)， 病理科(赵文明)

  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 通讯作者: 郭淑芹，E-mail： E-mail:guosq134221@163.com

Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus 

GUO  Hong-Ying, GUO  Shu-Qin, CHENG  Xiao-Dong, ZHAO  Wen-Ming, LI  Zhi-Hong, YANG  Qian   

  1. Department of Endocrinology, First Central Hospital of Baoding, Baoding 071000, China

  • Online:2013-03-08 Published:2013-02-25
  • Contact: GUO Shu-qin, E-mail: guosq134221@163.com E-mail:guosq134221@163.com

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摘要： 目的  研究SIRT1和p53在合并糖尿病子宫内膜癌的表达。方法 应用免疫组化法检测实验组39例合并2型糖尿病子宫内膜癌患者、对照组40例不合并糖尿病子宫内膜癌患者及25例正常子宫内膜标本的SIRT1、p53表达情况，分析指标间相关性。结果 实验组SIRT1和p53的阳性率分别为64.1％、59.0％，对照组分别为85.0％和52.5％。实验组SIRT1表达低于对照组(χ2 =4.561，P=0.033)。对照组SIRT1和p53的阳性率均高于正常子宫内膜组（χ2=21.462，P＜0.001；χ2=6.771，P=0.009）。SIRT1与p53的表达呈正相关(r =0.360，P=0.024)。结论 在子宫内膜癌患者中，高血糖可能下调SIRT1，SIRT1可能通过抑癌基因p53的沉默作用促进子宫内膜癌的形成。

关键词: 子宫内膜肿瘤, 糖尿病, 2型, SIRT1, 基因,p53

Abstract:  Objective To investigate the expressions and significances of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus. Methods Immunohistochemistry was carried out to examine the expressions of SIRT1 and p53 in 39 cases of endometrial carcinoma with diabetes mellitus and 40 cases of endometrial carcinoma without diabetes mellitus and 25 cases of normal endometrium, and the correlations between these indexs were analysed. Results The positive rate of SIRT1 and p53 in experimental group was 64.1％, 59.0％ respectively, and 85.0％, 52.5％ in control group. The positive rate of SIRT1 in experimental group was lower than control group (χ2=4.561, P=0.033). The positive rates of SIRT1 and p53 in control group were higher than normal endometrium (χ2=21.462, P＜0.001; χ2=6.771, P=0.009). Expression of SIRT1 was positively correlated with p53 (r = 0.360，P =0.024). Conclusions Hyperglycemia deregulates SIRT1 in endometrial carcinoma. SIRT1 may promote tumorigenesis by silence of p53.

Key words: Endometrial neoplasms, Diabetes mellitus, type 2, SIRT1, Genes, p53