国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 203-207.

• 综述 • 上一篇    下一篇

Hedgehog信号通路与乳腺癌干细胞

孙莹, 魏军民, 王秀问   

  1. 250012 济南，山东大学齐鲁医院肿瘤中心化疗科

  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 通讯作者: 魏军民 E-mail:weijunmin@sdu.edu.cn

Hedgehog signaling pathway and breast cancer stem cells

SUN  Ying, WEI  Jun-Min, WANG  Xiu-Wen   

  1.  Department of Chemotherapy, Cancer Center, Qilu Hospital of Shandong University, Jinan 250012, China

  • Online:2013-03-08 Published:2013-02-25
  • Contact: WEI Jun-min, E-mail: weijunmin@sdu.edu.cn E-mail:weijunmin@sdu.edu.cn

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被引次数

1

摘要： Hedgehog（HH）信号通路是经典的控制胚胎发育的信号传导途径，最近研究发现，该通路在肿瘤的发生和发展过程中发挥重要作用。HH信号对乳腺癌干细胞（BCSC）的干细胞特性的维持，及乳腺癌的复发、转移、耐药有密切的关系，有望成为针对BCSC治疗的新靶点。

关键词: 信号传导, 乳腺肿瘤, 肿瘤干细胞, Hedgehog

Abstract: Hedgehog (HH) signaling pathway is a classic signaling pathway which controls embryonic development. Recent studies show that HH signaling pathway plays an important role in the tumorigenesis and development of cancer. Breast cancer stem cell (BCSC) is closely associated with malignant tumor metastasis, relapse and treatment resistance. HH pathway plays crucial roles in maintaining the characters of BCSC, and will probably become a novel therapeutic target of breast cancers.

Key words: Signal transduction, Breast neoplasms, Neoplastic stem cells, Hedgehog