国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 43-46.

• 综述 • 上一篇    下一篇

醛酮还原酶超家族与肺癌

张丽娜, 岳文涛   

  1. 101149北京，首都医科大学附属北京胸科医院结核病胸部肿瘤研究所细胞生物学研究室
  • 出版日期:2013-01-08 发布日期:2013-01-15
  • 通讯作者: 岳文涛，E-mail: wentaoyue@hotmail.com E-mail:wentaoyue@hotmail.com

Aldo-keto reductase superfamily and lung cancer

ZHANG  Li-Na, YUE  Wen-Tao   

  1. Laboratory of Cell Biology,Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
  • Online:2013-01-08 Published:2013-01-15
  • Contact: Corresponding author: YUE Wen-tao, E-mail: wentaoyue@hotmail.com E-mail:wentaoyue@hotmail.com

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摘要： 醛酮还原酶（AKR）超家族是烟酰胺腺嘌呤二核苷酸磷酸（NADPH）依赖的氧化还原酶，作为多元醇代谢通路的限速酶，其活化或失活参与外界毒物代谢相关的肺癌的发生，并与肺癌抗药性产生相关，成为肺癌预后预测相关因子。

关键词: 肺肿瘤, 肿瘤形成过程, 抗药性, 醛酮还原酶超家族

Abstract: Aldehyde and ketone reductase (AKR) superfamily is NADPH-dependent oxidoreductase. As a rate-limiting enzyme in polyols metabolic pathway, the activation or inactivation of AKR involves in neoplastic process of lung cancer with the metabolism of environment toxic. AKR is related to drug resistance of chemotherapy, which will be the prognostic factor of lung cancer.

Key words: Lung neoplasms, Neoplastic processes, Drug resistance, Aldo-keto reductase superfamily