国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 690-693.

• 综述 • 上一篇    下一篇

mTOR与胃癌

辛利,王庆才   

  1. 271000  泰安市中心医院消化内一科
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 王庆才，E-mail: wqczs@163.com E-mail:wqczs@163.com

mTOR in gastric cancer

 XIN  Li, WANG  Qing-Cai   

  1. Department of Gastroenterology, Central Hospital of Taian, Taian 271000, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: WANG Qing-cai， E-mail:wqczs@163.com E-mail:wqczs@163.com

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被引次数

1

摘要： 哺乳动物雷帕霉素靶蛋白(mTOR) 是一种非典型的丝氨酸/苏氨酸蛋白激酶，属于磷脂酰肌醇激酶相关激酶(PIKK ) 蛋白家族成员。mTOR在肿瘤细胞生长、凋亡和肿瘤血管生成方面起着重要作用。目前以mTOR为靶点的分子靶向药物治疗已成为当前研究的热点。

关键词: 哺乳动物, 蛋白激酶抑制剂, 胃肿瘤

Abstract: Mammalian target of rapamycin (mTOR) is an atypical serine / threonine protein kinase, and belongs to the phosphatidylinositol kinaserelated kinase ( PIKK) family. mTOR plays an important role in tumor cell growth, apoptosis and tumor angiogenesis. Molecular therapy targeted mTOR has become a hot research topiccurrently.

Key words: Mammals, Protein kinase inhibitors, Stomach neoplasms