国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 252-254.

• 综述 • 上一篇    下一篇

聚肌胞与肿瘤免疫

程玉生, 夏靖燕, 徐峰   

  1. 310009 杭州, 浙江大学医学院附属第二医院呼吸科[程玉生（现工作单位皖南医学院弋矶山医院呼吸科），徐峰]；放疗科（夏靖燕）
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 夏靖燕，E-mail: xiajingyan2000@yahoo.com.cn E-mail:xiajingyan2000@yahoo.com.cn
  • 基金资助:

    浙江省科技厅钱江人才计划项目（2010B10080）,浙江省医药卫生优秀青年科技人才专项基金资助项目（2008QN016）

Polyinosinic-polycytidylic acid and tumor immunity

CHENG  Yu-Sheng, XIA  Jing-Yan, XU  Feng   

  1. Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: XIA Jing-yan, E-mail: xiajingyan2000@yahoo.com.cn E-mail:xiajingyan2000@yahoo.com.cn

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摘要： 聚肌胞是一种人工合成的病毒双链RNA的模拟物，具有重要的免疫调节功能。聚肌胞主要作用于Toll样受体3（TLR3）、维甲酸诱导基因Ⅰ（RIG-Ⅰ）和骨髓瘤分化相关基因-5（MDA-5）3种胞内受体，分别通过含TIR结构域的接头蛋白诱导干扰素β（TRIF）、干扰素β启动刺激剂激活下游信号转导通路，通过激活人体对肿瘤细胞的天然免疫及获得性免疫，从而发挥重要的抗肿瘤免疫调节作用。在黑色素瘤、乳腺癌、恶性胶质细胞瘤及肺癌等恶性肿瘤中对聚肌胞肿瘤免疫调节机制的进一步阐明将给肿瘤免疫治疗提供新的策略。

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Abstract: Polyinosinic-polycytidylic acid is a synthetic analog of double-stranded RNA, which plays a vital role in the regulation of immune system. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MAD-5) and retinoic acid inducible gene -Ⅰ (RIG-Ⅰ) are the main three intracellular receptors binding to polyinosinic-polycytidylic acid which activates human anti-tumor immune responses including the activation of innate immunity and acquired immunity through TIR-domain-containing adapter-inducing interferon-β (TRIF) and interferon-β. Thus, polyinosinic-polycytidylic acid plays an important role in regulating anti-tumor immune responses. The immunoregulation mechanisms of polyinosinic-polycytidylic acid in melanoma, breast cancer, malignant glioma and lung cancer have been clarified, which will provide new strategies for tumor immunotherapy.

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