国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 854-857.

• 综述 • 上一篇    下一篇

哺乳动物雷帕霉素靶蛋白及其与胃癌的关系

黄广岩, 史良会   

  1. 241000芜湖,安徽省皖南医学院附属弋矶山医院胃肠三科
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 史良会,E-mail:yueliang680@163.com E-mail:yueliang680@163.com
  • 基金资助:

    安徽省教育厅重点课题(KJ2011A264)

mTOR signalling pathway and gastric carcinoma

HUANG  Guang-Yan, SHI  Liang-Hui   

  1. The Third Department of Gastrointestinal, YijiShan Hospital of WanNan Medical College, Wuhu 241000, China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author: SHI Liang-hui,E-mail:yueliang680@163.com E-mail:yueliang680@163.com

摘要: 哺乳动物雷帕霉素靶蛋白(mTOR)信号途径在多种恶性肿瘤中存在异常激活或变异,该途径激活可以调控肿瘤细胞的增殖、存活以及转移能力,进而导致恶性肿瘤发生发展。雷帕霉素及其衍生物通过阻断mTOR通路的信号传递,抑制胃癌细胞生长,促进肿瘤坏死,并能与其他化疗药物产生协同作用,有望为胃癌预防和治疗提供有效的方法。

关键词: 胃肿瘤, 西罗莫司, 哺乳动物雷帕霉素靶蛋白

Abstract: Aberrations of the mammalian target of rapamycin (mTOR) signaling are frequently observed in many types of cancer. Activation of mTOR regulates tumor cell proliferation, survival and metastasis,and then results tumorigenesis and tumor developmet,Blocking the mTOR signaling pathway by rapamycin and its derivatives can inhibit gastric cancer cell growth and promote tumor necrosis and such effects can be synergistically improved by combined use of other chemotherapeutic agents.Thus,rapamyein and its derivatives may be effective in the prevention and treatment of gastric cancer.

Key words: color: black, font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA" lang="EN-US">Stomach neoplasms, Sirolimus, Mammalian target of rapamycin