国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 809-812.doi: 10.3760/cma.j.issn.1673422X.2015.11.003

• 论著 • 上一篇    下一篇

厄洛替尼联合全脑放疗治疗非小细胞肺癌脑转移的临床观察

王小磊, 刘德泽, 王民, 栾天燕   

  1. 071000 保定，河北大学附属医院肿瘤内科
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 王民，Email: 17497564@qq.com E-mail:17497564@qq.com

Clinical observation of erlotinib combined with whole brain radiation therapy for nonsmall cell lung cancer patients with brain metastases

 WANG  Xiao-Lei, LIU  De-Ze, WANG  Min, LUAN  Tian-Yan   

  1. Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Wang Min E-mail:17497564@qq.com

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1778

被引次数

43

摘要： 目的探讨表皮生长因子受体（EGFR）酪氨酸激酶抑制剂厄洛替尼联合全脑放疗治疗非小细胞肺癌（NSCLC）脑转移的临床疗效及不良反应，评价其有效性和安全性。方法选取病理证实的出现脑转移的NSCLC患者63例，采用随机数字表法分为厄洛替尼联合全脑放疗组（33例）和单纯全脑放疗组（30例），所有患者均接受全脑放疗，肿瘤吸收剂量（3 000～3 600）cGy/（10～12）F，厄洛替尼联合全脑放疗组患者自放疗开始应用厄洛替尼150 mg，口服，1次/d，直至放疗完成后至少2个月。全组病例于放疗结束2个月时进行疗效评估。结果厄洛替尼联合全脑放疗组和单纯全脑放疗组转移灶客观有效率和疾病控制率分别为54.6%、13.3%（χ2=11.744，P=0.001）和91.0%、60.0%（χ2=8.276，P=0.004），差异有统计学意义。两组总体客观有效率和疾病控制率分别为39.3%、10.0%（χ2=7.166，P=0.007）和84.8%、40.0%（χ2=7.759，P=0.005）。分层分析显示，厄洛替尼联合全脑放疗组中，EGFR突变阳性和阴性亚组的客观缓解率和疾病控制率分别为76.5%、33.3%（χ2=6.248，P=0.012）和100%、77.7%（χ2=4.093，P=0.043）。厄洛替尼联合全脑放疗组1年生存率和无进展生存率分别为57.6%、42.4%，明显高于单纯全脑放疗组的30.0%、16.7%，差异均具有统计学意义（χ2=4.840，P=0.028；χ2=4.950，P=0.026）。厄洛替尼联合全脑放疗组主要不良反应为皮疹、腹泻，均为轻中度，未发生治疗相关性死亡。结论厄洛替尼联合全脑放疗对NSCLC脑转移具有一定的疗效，且不良反应轻微，可以作为NSCLC脑转移的一种治疗选择。

关键词: 癌, 非小细胞肺, 肿瘤转移, 厄洛替尼

Abstract: ObjectiveTo study clinical efficacy and toxicity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib combined with whole brain radiotherapy in the nonsmall cell lung cancer (NSCLC) with brain metastases and to evaluate its effectiveness and safety. MethodsIn accordance with the random digital number method, Sixtythree NSCLC patients with brain metastases were divided into erlotinib combined with whole brain radiation therapy group (33 cases) and whole brain radiotherapy alone group (30 cases), each patient received the whole brain radiotherapy, DT (3 0003 600)cGy/(1012)F. Erlotinib combined with whole brain radiotherapy group received oral erlotinib, at a dose of 150 mg per day from the beginning of the whole brain radiotherapy, at least two months until after the completion of radiation therapy. All patients were evaluated in the efficacy of radiotherapy at the end of two months. ResultsThe metastases objective response rate and disease control rate of erlotinib combined with whole brain radiation therapy group and whole brain radiotherapy alone group were respectively 54.6%, 13.3% (χ2=11.744, P=0.001) and 91.0%, 60.0% (χ2=8.276, P=0.004).  The objective response rate and disease control rate in the two groups were respectively 39.3%, 10.0% (χ2=7.166, P=0.007) and 84.8%, 40.0% (χ2=7.759, P=0.005). Stratified analysis showed that in erlotinib combined with whole brain radiotherapy group, the objective response rate and disease control rate of EGFR mutation positive and negative subgroup were respectively 76.5%, 33.3% (χ2=6.248, P=0.012) and 100%, 77.7% (χ2=4.093, P=0.043). The 1year survival and progressionfree survival rates of the two groups were 57.6%, 30.0% and 42.4%, 16.7%, the differences were statistically significant (χ2=4.840, P=0.028; χ2=4.950, P=0.026). The main adverse events of erlotinib combined with whole brain radiotherapy group were mild to moderate rash, diarrhea, and no treatmentrelated deaths occurred. ConclusionErlotinib combined with whole brain radiotherapy for the NSCLC patients with brain metastases has some effect, and the adverse reactions are mild, which can be used as a treatment option for NSCLC brain metastases.

Key words: Carcinoma, nonsmallcell lung, Neoplasm metastasis, Erlotinib