国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 813-816.doi: 10.3760/cma.j.issn.1673422X.2015.11.004

• 论著 • 上一篇    下一篇

复方谷氨酰胺在胃癌术后辅助治疗中的应用研究

王福立,王兰华,姜伟,祝爱峰,李明,张建东   

  1. 255000 山东省淄博市中心医院肿瘤科（王福立）；山东省临清市人民医院肿瘤科（王兰华）；潍坊医学院研究生院（姜伟）；山东省莱芜市人民医院放疗科（祝爱峰、李明）；山东省千佛山医院肿瘤放疗科（张建东）
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 张建东，Email：zhangjd165@sina.com E-mail:zhangjd165@sina.com
  • 基金资助:

    山东省科技发展计划项目（2014GGH218042）

Clinical study of compound glutamine for adjuvant therapy after radical surgery in gastric cancer

Wang Fuli, Wang Lanhua, Jiang Wei, Zhu Aifeng, Li Ming, Zhang Jiandong.   

  1. Department of Oncology, Central Hospital of Zibo, Shandong Province, Zibo 255000, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Zhang Jiandong E-mail:zhangjd165@sina.com

PDF

1107

被引次数

2

摘要： 目的观察复方谷氨酰胺在胃癌术后辅助治疗中的临床疗效。  方法将63例胃癌根治术后的患者采用随机数字表法随机分为试验组和对照组，试验组32例，给予三维适形放疗同步卡培他滨单药方案化疗，同时口服复方谷氨酰胺肠溶胶囊。对照组31例，仅给予同步放化疗。结果试验组生命质量评分为良好和较好者分别占40.6%和34.4%，明显高于对照组的16.1%和12.9%,差异有统计学意义(χ2＝4.63,P＝0.03；χ2＝4.00,P＝0.04)。试验组的恶心、呕吐和腹痛、腹泻的发生率分别为31.3%和37.5%，明显低于对照组的61.3%和64.5%，差异有统计学意义（χ2＝5.72,P＝0.02；χ2＝4.60,P＝0.03）。试验组的胃肠道不良反应主要为Ⅰ度和Ⅱ度，未出现Ⅲ、Ⅳ度不良反应。试验组比对照组应用止泻药(21.9%∶48.4%)及止痛药（15.6%∶38.7%）的比例明显减少（χ2＝4.87,P＝0.03；χ2＝4.26,P＝0.04）。结论胃癌术后辅助放化疗患者补充复方谷氨酰胺能够改善患者生命质量，降低放化疗引起的胃肠道不良反应，提高患者的治疗依从性,从而顺利完成治疗。

关键词: 胃肿瘤, 放射疗法, 药物疗法, 谷氨酰胺

Abstract: ObjectiveTo evaluate the clinical effect of compound glutamine in the adjuvant treatment after radical surgery of gastric cancer. MethodsA total of 63 cases with gastric cancer after radical resection were randomly divided into treatment group and control group, according to random number table. 32 patients in treatment group received simultaneous threedimensional conformal radiotherapy with capecitabine monotherapy regimen, while oral administration of compound glutamine entericcoated capsules. 31 cases in control group only received chemoradiotherapy. ResultsIn treatment group, the quality of life score for the excellent and good accounted for 40.6% and 34.4%, significantly higher than 16.1% and 12.9% in control group respectively (χ2＝4.63, P＝0.03; χ2＝4.00, P＝0.04). The incidence of nausea and vomiting, abdominal pain and diarrhea in treatment group respectively were 31.3% and 37.5%, significantly less than 61.3% and 64.5% in control group with statistical significance （χ2＝5.72, P＝0.02; χ2＝4.60, P＝0.03）. The incidence of gastrointestinal reactions in treatment group were mainlyⅠand Ⅱdegrees, and ⅢⅣ degree of gastrointestinal reactions were not appear. While the antidiarrheal drugs (21.9% vs. 48.4%) and analgesics drugs (15.6% vs. 38.7%) in the treatment group were significantly reduced compared with the control group （χ2＝4.87, P＝0.03; χ2＝4.26, P＝0.04）. ConclusionBy administration of compound glutamine in the course of adjuvant chemotherapy after radical surgery of gastric cancer can improve the quality of life, reduce chemotherapyinduced gastrointestinal side effects, improve treatment compliance, and successfully complete the treatment.

Key words: Stomach neoplasms, Radiotherapy, Drug therapy, Glutamine