国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (9): 566-569.doi: 10.3760/cma.j.issn.1673-422X.2019.09.012

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微小RNA与弥漫大B细胞淋巴瘤

孙烨1，盛立霞2，欧阳桂芳2   

  1. 1宁波大学医学院临床内科系315211； 2宁波市第一医院血液科315000
  • 收稿日期:2019-07-22 出版日期:2019-09-08 发布日期:2019-09-08
  • 通讯作者: 盛立霞 E-mail:slx800408@163.com
  • 基金资助:
    国家自然科学基金（81401321）；浙江省基础公益研究计划（LGF19H080002）；浙江省医药卫生科技计划（2018PY052）

MicroRNAs and diffuse large B cell lymphoma

Sun Ye1, Sheng Lixia2, Ouyang Guifang2   

  1. 1Department of  Clinical Medicine, Medical School of Ningbo University, Ningbo 315211, China; 2Department of Hematology, Ningbo  First Hospital, Ningbo 315000, China
  • Received:2019-07-22 Online:2019-09-08 Published:2019-09-08
  • Contact: Sheng Lixia E-mail:slx800408@163.com
  • Supported by:
    National Natural Science Foundation of China (81401321); Basci Public Welfare Research Project of Zhejiang Province (LGF19H080002); Medcical Health Science and Technology Project of Zhejiang Provincial Health Commission (2018PY052)

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摘要： 弥漫大B细胞淋巴瘤（DLBCL）发病的分子机制目前尚未完全阐明，表观遗传学在其发生发展中发挥了重要作用。微小RNA（miRNA）是表观遗传学中重要的一部分，参与DLBCL的发生发展。相关研究发现miRNA不仅可作为DLBCL的分子诊断标志物，而且可用于判断其预后和治疗效果。

关键词: 淋巴瘤, 大B细胞, 弥漫性, 微RNAs, B-淋巴细胞, 诊断, 预后

Abstract: The molecular mechanism of diffuse large B cell lymphoma (DLBCL) has not been fully elucidated, and epigenetics plays an important role in its development. MicroRNAs (miRNAs) are important parts of epigenetics, which are involved in the occurrence and development of DLBCL. Relevant studies have found that miRNAs can not only be used as molecular diagnostic markers of DLBCL, but also be used to judge the prognosis and treatment effect of DLBCL.

Key words: Lymphoma, large Bcell, diffuse, MicroRNAs, B-lymphocytes, Diagnosis, Prognosis