关键词: 癌, 非小细胞肺, 灌洗, 治疗结果, 洛铂

Abstract: ObjectiveTo evaluate the clinical efficacy and safety of lobaplatin for pleural lavage in the radical operation of nonsmall cell lung cancer (NSCLC). MethodsA total of 100 patients with NSCLC from June 2015 to December 2015 in Affiliated Hospital of Guilin Medical University were collected, and  were divided into experimental group and control group according to the patients′ or family′s wishes for treatment, with 50 cases in each group. The lobectomy and mediastinal lymph node dissection were performed for patients in the two groups. During the operation of the experimental group, we flushed the chest with 42 ℃ distilled water 2 000 ml first, then we washed and steeped the pleura with 500 ml of 5% glucose injection containing 50 mg lobaplatin for 10 min, in the end sucked out the washing fluid. During the operation, patients of the control group only received a treatment of same amount of distilled water. Then, the short and longterm effects and adverse reaction were tracked and compared. ResultsThe thoracic drainage of the first 3 days after operation in experimental group was (1 150±150) ml, and the control group was (790±110) ml, with a significant difference (t=3.352, P=0.029). The numbers of white blood cell ［(12.5±1.2)×109/L vs. (12.8±1.0)×109/L; t=0.333, P=0.756］, the platelets ［(235.2±52.5)×109/L vs. (236.5±34.5)］×109/L; t=0.036, P=0.973］, the creatinine ［(74.2±9.1) μmol/L vs. (75.2±8.7) μmol/L; t=0.138, P=0.897］, urea nitrogen ［(4.8±2.1) mmol/L vs. (5.5±2.4) mmol/L; t=0.391, P=0.716］, glutamicoxalacetic transaminase ［(9.6±3.8) U/L vs. (8.2±2.5) U/L; t=0.533, P=0.622］ and glutamicpyruvic transaminase ［(22.4±9.2) U/L vs. (21.8±6.4) U/L; t=0.093, P=0.931］ showed no significant differences between experimental group and control group. The positive rate of drainage exfoliative cells (4.0% vs. 16.0%) and ipsilateral recurrence rate (0 vs. 30.0%) of experimental group were lower than those of control group, with significant differences (χ2=4.000, P=0.046; χ2=17.647, P＜0.001). There was no death in experimental group during the followup period, and 2 patients in control group died. The rates of adverse reactions such as incisional pain (16.0% vs. 12.0%), nausea (10.0% vs. 14.0%), vomiting (4.0% vs. 0) and diarrhea (4.0% vs. 0) showed no significant differences between experimental group and control group (χ2=0.332, P=0.564; χ2=0.379, P=0.538; χ2=0.510, P=0.475; χ2=0.510, P=0.475). ConclusionThe application of lobaplatin for pleural lavage in the radical operation of lung cancer is safe and effective, which can significantly reduce the rate of ipsilateral recurrence.

Key words: Carcinoma, nonsmallcell lung, Irrigation, Treatment outcome, Lobaplatin