国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (2): 154-157.doi: 10.3760/cma.j.issn.1673-422X.2014.02.022

• 论著 • 上一篇    下一篇

非霍奇金淋巴瘤血清VEGF水平与疗效及预后的相关性研究

柳影, 程颖   

  1. 130012 长春，吉林省肿瘤医院胸部肿瘤内科
  • 收稿日期:2013-08-19 修回日期:2013-12-06 出版日期:2014-02-08 发布日期:2014-01-26
  • 通讯作者: 程颖，E-mail: chengying@csco.org.cn E-mail:chengying@csco.org.cn
  • 基金资助:

    吉林省卫生厅课题（2006Z119）

Correlation research of VEGF in serum and curative effect and prognosis of nonHodgkin lymphoma

Liu  Ying, Cheng  Ying   

  1. Department of Thoracic Physical Oncology, Jilin Provincial Tumor Hospital, Changchun 130012, China
  • Received:2013-08-19 Revised:2013-12-06 Online:2014-02-08 Published:2014-01-26
  • Contact: Cheng Ying E-mail:chengying@csco.org.cn

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摘要： 目的 研究非霍奇金淋巴瘤（NHL）患者血管内皮生长因子（VEGF）的表达及其与化疗疗效和预后的相关性，探讨VEGF作为NHL疗效预测和预后评估标志物的可能性。方法 采用酶联免疫吸附技术检测60例NHL患者治疗前后血清VEGF水平，并观察VEGF水平与疗效和生存的关系，同时检测20例正常对照者血清VEGF水平。结果 NHL患者血清VEGF为(338.64±259.31) pg/ml，明显高于正常对照者的(72.57±26.16) pg/ml（t=7.829，P=0.000）。NHL患者血清VEGF水平与国际预后指数（IPI）及结外侵犯相关（t=-3.747，P=0.002；t=-3.000，P=0.005），而与年龄、性别、分期、美国东部肿瘤协作组体力状态（ECOG PS）评分无明显相关性。治疗后部分和完全缓解（PR和CR）患者血清VEGF水平较治疗前明显降低（t=2.729，P=0.010）。血清VEGF水平与患者生存期无明显相关性（t=-0.563，P=0.577）。结论 初治NHL患者血清VEGF水平高于正常对照者，尤其与IPI和结外侵犯数量相关；血清VEGF水平变化与化疗疗效相关，但与生存期无明显相关性。

关键词: 淋巴瘤, 非霍奇金, 血管内皮生长因子类

Abstract: Objective To study the expression of vascular endothelial growth factor (VEGF)  in nonHodgkin′s lymphoma (NHL) and its correlation with chemotherapy effect and prognosis, further to study the possibility that VEGF can be as the biomarker of prognosis and efficacy prediction for NHL. MethodsThe levels of VEGF in 60 NHL patients were detected by enzymelinked immunosorbent assay before and after treatment. The relationships between the levels of VEGF and effects and overall survival were observed. The VEGF levels of 20 healthy person as control group were detected. ResultsThe average level of VEGF in NHL patients was (338.64±259.31) pg/ml, which was significantly higher than that of normal control (72.57±26.16) pg/ml (t=7.829, P=0.000). Serum VEGF level in NHL patients was relative to the international prognostic index (IPI) and extracapsular extension (t=-3.747, P=0.002; t=-3.000, P=0.005). There was no correlation with age, sex, stage and Eastern Cooperative Oncology Group performance status (ECOG PS). After treatment the VEGF level was significantly lower in the patients who achieved partial and complete remission (PR and CR) (t=2.729, P=0.010). There was no significant correlation between VEGF level and survival time (t=-0.563, P=0.577). ConclusionThe serum VEGF level of initial treatment patient with nonHodgkin′s lymphoma is higher than normal control, especially relates with the IPI and the number of extranodal extension. The changes of serum VEGF level associate with chemotherapeutic effect, but have no obvious correlation with survival time.

Key words: Lymphoma, nonHodgkin, Vascular endothelial growth factors