国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 148-150.doi: 10.3760/cma.j.issn.1673422X.2017.02.019

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CXCL5/CXCR2生物轴在胰腺癌中的研究进展

黄帆,景鸿恩   

  1. 810000西宁，青海大学附属医院肝胆胰一科
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 景鸿恩，Email: huangsejinfan@sohu.com E-mail:huangsejinfan@sohu.com

CXCL5/CXCR2 biological axis in pancreatic cancer

Huang Fan, Jing Hongen   

  1. Hepatobiliary and Pancreatic Surgery Department I, Qinghai University Affiliated Hospital, Xi′ning 810000, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Jing Hongen E-mail:huangsejinfan@sohu.com

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摘要： 胰腺癌的增殖、进展、转移是一个多因素参与的过程。其中，CXC类趋化因子配体5（CXCL5）能够识别并结合CXC类趋化因子受体2（CXCR2），通过细胞自分泌或旁分泌等途径激活或调节信号通路的表达。CXCL5/CXCR2生物轴能够在胰腺癌细胞的增殖、黏附、侵袭、转移和预后中发挥作用，并且与胰腺癌血管及淋巴管生成等相关。直接或间接调控CXCL5/CXCR2在胰腺癌中的表达，有望成为靶向治疗胰腺癌的有效手段。

关键词: 胰腺肿瘤, 趋化因子CXCL5, 受体, 白细胞介素8B

Abstract: The proliferation, progression and metastasis of pancreatic cancer are complicated processes caused by multiple factors. C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2), and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells. CXCL5/CXCR2 biological axis plays important roles in proliferation, adhesion, progression, metastasis and prognosis of pancreatic cancer, and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer. So, direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.

Key words: Pancreatic neoplasms, Chemokine CXCL5, Receptor, interleukin-8B