国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 533-536.doi: 10.3760/cma.j.issn.1673422X.2014.07.016

• 综述 • 上一篇    下一篇

骨肿瘤的发生发展及转移

杨澄,苏宏伟,任慧文,李宏伟   

  1. 130021 长春，吉林大学中日联谊医院骨外科
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 李宏伟，Email：lihw@163.com E-mail:lihw@163.com

The occurrence,development and metastasis in bone neoplasms

 YANG  Cheng, SU  Hong-Wei, REN  Hui-Wen, LI  Hong-Wei   

  1. Department of Orthopedics, ChinaJapan Union Hospital, Jilin University, Changchun 130021, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Li Hongwei E-mail:lihw@163.com

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1365

被引次数

3

摘要： 骨肿瘤中骨肉瘤（OS)和尤文肉瘤（ES）因具有较复杂的发生、发展、转移机制和不良预后而受到医学界的广泛关注。研究表明原癌基因的激活和抑癌基因的突变、凋亡信号缺失和乏氧诱导因子等均参与OS和ES的发生、发展及转移。阐明骨肿瘤复杂的病理机制能为OS和ES提供更有效的靶向治疗手段和降低患者的死亡率。

关键词: 骨肿瘤, 骨肉瘤, 尤文肉瘤, 肿瘤转移

Abstract: Bone tumor is one kind of malignant tumor which threats life among children and adolescent. Osteosarcoma(OS) and Ewing sarcoma(ES) have been paid much attention by medical community because of their complex occurrence, development, metastasis mechanism and poor prognosis. The research showed that activation of protooncogene and mutation of suppressor gene, absence of apoptosis signal and hypoxiainducible factor (HIF) all participated in the occurrence, development and metastasis of OS and ES. It is suggested that clarified pathomechanism of bone tumors could provide more effective therapeutic strategies and lower the mortality of patients.

Key words: Bone neoplasms, Osteosarcoma, Ewing sarcoma, Neoplasm metastasis