腹膜转移癌的发病机制与免疫治疗临床研究进展

doi:10.3760/cma.j.cn371439-20250106-00055

摘要/Abstract

摘要：

腹膜转移癌是晚期恶性肿瘤的常见表现，其复杂的病理特征和独特的免疫抑制微环境使传统治疗效果有限。目前，腹膜转移癌的免疫治疗显示出了一定的潜力，但仍面临诸多挑战。未来的研究应聚焦新免疫靶点开发，局部与全身用药方式相结合，通过单细胞基因组学和空间转录组技术揭示肿瘤微环境特征，并借助人工智能筛选适用人群，有望有效改善患者生存。

关键词: 腹膜转移癌, 免疫微环境, 免疫检查点抑制剂, 细胞疗法, 联合治疗

Abstract:

Peritoneal carcinomatosis is a common manifestation of advanced malignant tumors. Its complex pathological features and unique immunosuppressive microenvironment limit the effectiveness of traditional treatment. At present， immunotherapy for peritoneal carcinomatosis shows certain potential， but still faces many challenges. Future research should focus on the development of new immunotherapy targets， the combination of local and systemic drug delivery approaches， the characterization of the tumor microenvironment using single-cell genomics and spatial transcriptome technologies， and the screening of appropriate populations using artificial intelligence， which is expected to effectively improve patient survival.

Key words: Peritoneal carcinomatosis, Immune microenvironment, Immune checkpoint inhibitor, Cell therapy, Combination therapy

纪淳望, 李松, 刘联. 腹膜转移癌的发病机制与免疫治疗临床研究进展[J]. 国际肿瘤学杂志, 2025, 52(5): 325-330.

Ji Chunwang, Li Song, Liu Lian. Progress of pathogenesis and clinical research on immunotherapy for peritoneal carcinomatosis[J]. Journal of International Oncology, 2025, 52(5): 325-330.

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