EGFR突变非小细胞肺癌脑转移靶向治疗进展

doi:10.3760/cma.j.cn371439-20240318-00121

摘要/Abstract

摘要：

非小细胞肺癌（NSCLC）脑转移的患者预后较差，酪氨酸激酶抑制剂（TKI）显著改善了表皮生长因子受体（EGFR）基因敏感突变患者的预后，TKI与放疗、化疗、抗血管生成治疗等联合应用能改善EGFR突变NSCLC脑转移患者的生存，但不同联合方案之间如何选择，获益的优势人群等问题仍需要进行更深入的临床研究。

关键词: 癌，非小细胞肺, 肿瘤转移, 放射疗法, 分子靶向治疗, 药物疗法，联合

Abstract:

Patients with brain metastases from non-small cell lung cancer （NSCLC） generally have a poor prognosis. Tyrosine kinase inhibitors （TKIs） have significantly improved the prognosis of patients with sensitizing mutations in the epidermal growth factor receptor （EGFR） gene. Combining TKIs with other treatments such as radiotherapy， chemotherapy， and anti-angiogenic therapy can improve survival of patients with EGFR-mutant NSCLC brain metastases. However， more in-depth clinical studies are needed to determine the best combination strategies and to identify which patient groups will benefit the most from these approaches.

Key words: Carcinoma， non-small-cell lung, Neoplasm metastasis, Radiotherapy, Molecular targeted therapy, Drug therapy， combination

罗毅君, 姚伟荣, 王晓莉. EGFR突变非小细胞肺癌脑转移靶向治疗进展[J]. 国际肿瘤学杂志, 2024, 51(11): 717-722.

Luo Yijun, Yao Weirong, Wang Xiaoli. Targeted therapeutic progression of EGFR mutation in non-small cell lung cancer with brain metastasis[J]. Journal of International Oncology, 2024, 51(11): 717-722.

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