Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (5): 367-370.doi: 10.3760/cma.j.issn.1673422X.2015.05.013

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Development of ABCC4 on various tumors and chemotherapy drugs

  

  1. Department of Cellular & Molecular Biology, Beijing Chest Hospital, Capital Medical University
  • Online:2015-05-08 Published:2015-05-12
  • Contact: Yue Wentao yuewt2000@yahoo.com

Abstract: ATP binding cassette C4 (ABCC4, MRP4) plays an important role in transshipment physiologic, endogenous or exogenous substances. The over expression of ABCC4 gene has been found in many kinds of solid tumors and hematological malignancies. The target gene also influences metastasis and recurrence process. ABCC4 can reduce the intracellular concentration and the sensitivity of various chemotherapy drugs, which is bad for prognosis.

Key words: Neoplasms/Drug therapy/Drug resistance, neoplasm/ATPbinding cassette transporter C4