Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (4): 295-298.

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Variations of biomarkers in gastrointestinal stromal tumor and prognoses of the patients and targeted drug sensitivity

SUN  Wen, CHEN  Jin-Fei   

  1. Department of Oncology, the First Hospital of Nanjing, Affiliated Hospital of Nanjing Medical University, Nanjing 210006, China

  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: CHEN Jin-fei, E-mail: jinfeichen@sohu.com E-mail:jinfeichen@sohu.com

Abstract: Many researches show that the prognosis of gastrointestinal stromal tumor (GIST) are related to numerous variations of biomarkers such as numeric chromosomal aberrations or nuclear/mitochondrial microsatellite instability. In addition, the changes of proto-oncogene and tumor-suppressor gene are found to influence the prognosis of GIST. The kit and platelet-derived growth factor receptor a mutation are correlated with GIST progression, metastasis and targeted drug sensitivity, and then influence the prognosis of GIST.

Key words: Gastrointestinal stromal tumors, Biological markers, Prognosis, Molecular targeted therapy