Expression and clinical significance of HIF-1α and OPN in esophageal cancer tissues

doi:10.3760/cma.j.issn.1673-422X.2019.08.004

Abstract

Abstract: Objective To discuss the expression and clinical significance of hypoxia-inducible factor-1α (HIF-1α) and osteopontin (OPN) in esophageal cancer tissues. Methods A total of 100 patients with esophageal cancer in Enshi Tujia and Miao Autonomous Prefecture Central Hospital of Hubei Province from January 2015 to January 2017 were selected. The expressions of HIF-1α and OPN in esophageal cancer and adjacent tissues were detected by immunohistochemistry. The relationships between HIF-1α and OPN expressions and clinical pathological characteristics of esophageal cancer patients, as well as the correlation between them were analyzed. Results The positive rates of HIF-1α and OPN expression in esophageal cancer tissues were 70.00% (70/100) and 64.00% (64/100), which were significantly higher than the 14.00% (14/100) and 8.00% (8/100) in adjacent tissues, and the differences were statistically significant (χ²=64.368, P<0.001; χ²=68.056, P<0.001). The expression of HIF-1α was correlated with TNM stage, depth of invasion and lymph node metastasis (χ²=30.159, P<0.001; χ²=17.493, P<0.001; χ²=16.357, P<0.001), but it was not correlated with sex, age, tumor diameter and differentiation (all P>0.05). The expression of OPN was correlated with TNM stage, depth of invasion and lymph node metastasis (χ²=12.558, P=0.002; χ²=15.395, P<0.001; χ²=17.056, P<0.001), but it was not correlated with sex, age, tumor diameter and differentiation (all P>0.05). There was the positive correlation between HIF-1α and OPN expression in esophageal cancer tissues (χ²=61.144, P<0.001, C=0.616). The 2-year survival rates of HIF-1α and OPN positive patients in esophageal cancer tissues were 51.43% and 50.00% respectively, which were significantly lower than those of HIF-1α and OPN negative patients (80.00% and 77.78%), and the differences were statistically significant (χ²=7.143, P=0.008; χ²=7.407, P=0.006). Conclusion HIF-1α and OPN are highly expressed in esophageal cancer tissues, and their high expression may be related to poor survival prognosis of esophageal cancer.

Key words: Esophageal neoplasms, Hypoxia-inducible factor 1, alpha subunit, Osteopontin, Prognosis

Wang Miao, Liu Peijun. Expression and clinical significance of HIF-1α and OPN in esophageal cancer tissues[J]. Journal of International Oncology, 2019, 46(8): 466-470.

References

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