Research progress of patient-derived organoid models in metastatic cancer

doi:10.3760/cma.j.cn371439-20250901-00122

Abstract

Abstract:

Patient-derived organoids （PDOs） are self-assembling， microscopic three-dimensional structures cultivated in vitro from stem cells. They can highly recapitulate the structural， physiological， and genetic characteristics of the original tissue and demonstrate a high correlation with patients' clinical efficacy. In recent years， PDOs models have emerged as an ideal tool for investigating the mechanisms of tumor metastasis and developing corresponding therapeutic strategies. Further exploration of the application and latest research progress regarding PDOs models in various types of metastatic cancers will provide a critical theoretical foundation for advancing precision anti-tumor treatment strategies.

Key words: Organoids, Neoplasm metastasis, Precision medicine, Drug resistance

Yu Ziwei, Zhuang Qingchun, Sun Jing, Li Xinyu, Sha Dan. Research progress of patient-derived organoid models in metastatic cancer[J]. Journal of International Oncology, 2025, 52(11): 714-719.

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