Journal of International Oncology ›› 2016, Vol. 43 ›› Issue (11): 858-860.doi: 10.3760/cma.j.issn.1673-422X.2016.11.015

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MicroRNAs and esophageal squamous cell carcinoma

Chen Jun, Li Jie   

  1. First Ward of Department of Thoracic Radiotherapy, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030013, China
  • Received:2016-02-03 Online:2016-11-08 Published:2016-11-02
  • Contact: Li Jie E-mail:lijie942003@163.com

Abstract: MicroRNAs (miRNAs) can influence the proliferation, apoptosis, invasion and metastasis of esophageal squamous cell carcinoma (ESCC) cells by signal transduction, epithelialmesenchymal transition, angiogenesis and other regulating mechanisms. Specific serum miRNAs can serve as novel diagnostic and prognostic biomarkers of ESCC. Recent studies have indicated that miRNAs can improve the radiation sensitivity and even reverse multidrug resistance of ESCC, holding great clinical value.

Key words: MicroRNAs, Esophageal neoplasms