Abstract: Apolipoptotein A1 is the main component of highdensity lipoprotein cholesterol in the plasma, which plays an important role in the lipid transportation and metabolism. It is closely related with cardiovascular disease, liver disease, hereditary amyloidosis and so on. CA125， as an important biomarker， has been widely used for the diagnosis and monitoring treatment of ovarian cancer. Improved sensitivity and specificity of diagnosis are obtained when it is combined with other tumor markers, especially CA125. As reported recently， it also  is related with the generation, progress and prognosis of ovarian cancer. It has been promising to be a new kind of treatment.

Key words: Ovarian neoplasms, Tumor markers, biological, Apolipoprotein A1