Abstract: LASS gene family is a group of highly conserved and longevous gene LASS protein has a ceramide synthase activity, which can synthesize different types of ceramides. Ceramide is a key intermediate in tumor cells growth, signal transduction and other aspects. Thus it is inferred that the expression of LASS gene can suppress the occurrence and development of tumor within a certain range.

Key words: Ceramides, Genes, tumor suppressor, Neoplastic process