Abstract: Surgical resection and liver transplantation are still the preferred treatments for patients with hepatocellular carcinoma (HCC). For the patients with advanced HCC which are not suitable for surgical resection, traditional chemotherapy can not improve the prognosis. Molecular targeted therapy is a new method and tendency in the treatment of HCC. Multiple targets inhibitors, vascular endothelial growth factor inhibitors and monoclonal antibodies for HCC are widely researched and applied.

Key words: Carcinoma, hepatocellular, Molecular targeted drugs