Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (11): 848-850.

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EML4-ALK fusion gene in non-small cell lung cancer

WANG  Meng, YANG  Ji-Yuan   

  1. Department of Medical Oncology,the First Affiliated Hospital,Yangtze University ,Jingzhou 434100,China
  • Online:2012-11-08 Published:2012-11-16

Abstract: EML4-ALK fusion oncogene represents a new molecular target which appears mainly in lung adenocarcinoma. EML4-ALK is detected more frequently in young non-small-cell lung cancer patients who never or light smoke. ALK inhibitors(crizotinib)for the treatment of the EML4-ALK-positive non-small cell lung cancer has a high response rate. This finding can improve the individual treatment of non-small cell lung cancer.

Key words: Carcinoma, non-small-cell, Lung neoplasms, Tumor markers