Abstract: Skin toxicities are the most common adverse effects of epidermal growth factor receptor inhibitors(EGFRI). It can result in significant physical and psychological discomfort, and even leads to interruption or dose modification, and consequently affect the curative effect. Nowadays this adverse effect has attracted lot of attention. It is proposed that clinical management and treatment measures for skin toxicities should be further studied to improve the patients life quality, and guarantee the continuity and best curative 〖JP2〗effect of the treatment. But more researches on the pathogenesis and its prognostic significance are still expected.

Key words: Receptor, epidermal growth factor, Drug eruptions