国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (1): 5-7.doi: 10.3760/cma.j.issn.1673-422X.2016.01.002

• 论著 • 上一篇    下一篇

S100A11在非小细胞肺癌中的表达及其临床意义

陈晓萍, 浦勇, 冯静洁, 华东   

  1. 214062 无锡，江南大学附属医院肿瘤内科（陈晓萍、华东），病理科（浦勇、冯静洁）
  • 收稿日期:2015-06-15 出版日期:2016-01-08 发布日期:2015-12-03
  • 通讯作者: 华东 E-mail:wx89211@163.com

Expression and clinical significance of S100A11 in non-small cell lung cancer

Chen Xiaoping, Pu Yong, Feng Jingjie, Hua Dong   

  1. Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China
  • Received:2015-06-15 Online:2016-01-08 Published:2015-12-03
  • Contact: Hua Dong E-mail:wx89211@163.com

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摘要： 目的 探讨钙离子结合蛋白S100家族成员S100A11在非小细胞肺癌（NSCLC）组织的表达及其与临床病理特征的关系。方法 采用免疫组织化学SP法检测S100A11蛋白在112例NSCLC组织（A组）及其相应癌旁组织（B组）和10例正常肺组织（C组）的表达，分析其与NSCLC临床病理特征的关系。结果 A组S100A11蛋白低表达24例（24/112，21.4%），高表达88例（88/112，78.6%）；B组S100A11蛋白均为低表达（112/112，100.0%）；C组S100A11蛋白表达均为阴性表达（10/10，100.0%），3组间差异有统计学意义（χ2=153.634，P＜0.001）。S100A11蛋白表达水平与肿瘤的病理类型(χ2=6.807，P=0.009）、分化程度（χ2=5.029，P=0.025）和局部淋巴结转移（χ2=11.721，P=0.001）有相关性，与性别（χ2=0.020，P=0.888）、年龄（χ2=0.816，P=0.366）及肿瘤大小（χ2=0.406，P=0.524）无关。结论 S100A11蛋白在NSCLC组织中表达增高，与NSCLC的生物学行为特性有关，可能参与NSCLC的发生发展，有望成为NSCLC诊断、预后的潜在靶分子。

关键词: 癌, 非小细胞肺, 免疫组织化学, S100A11

Abstract: Objective To investigate the expression of S100A11 protein in nonsmall cell lung cancer (NSCLC) and its association with clinical and pathological characteristics. MethodsThe expressions of S100A11 protein in 112 NSCLC tumor tissues (group A), tumoradjacent tissues (group B) and 10 normal lung tissues (group C) were detected by immunohistochemical SP method. The association of S100A11 expression with clinical pathological characteristics was analyzed. ResultsThe percentage of the cases with high expression cases of S100A11 protein was 78.6% (88/112), and the low expression rate was 21.4 % (24/112) in group A. The low expression rate of S100A11 protein was 100.0% (112/112) in group B. The negative expression rate of S100A11 protein was 100.0% (10/10) in group C. The difference of S100A11 expression among the three groups was statistically significant (χ2=153.634, P<0.001). The S100A11 expression was associated with pathological type (χ2=6.807, P=0.009), differentiated degree (χ2=5.029, P=0.025), regional lymph node metastasis (χ2=11.721, P=0.001) in NSCLC, but it was not associated with gender (χ2=0.020, P=0.888), age (χ2=0.816, P=0.366) and tumor size (χ2=0.406, P=0.524). ConclusionS100A11 is highly expressed in NSCLC, which is closely related with biological behavioral characteristics. S100A11 may participate in the occurrence and development of NSCLC, and it is expected to become the potential target of diagnosis and prognosis in patients with NSCLC.

Key words: Carcinoma, non-small-cell lung, Immunohistochemistry, S100A11