国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (11): 872-874.doi: 10.3760/cma.j.issn.1673-422X.2014.11.022

• 论著 • 上一篇    下一篇

腹腔镜胃癌手术腹腔冲洗液中sICAM-1、sCD44v6表达的影响及其意义

  

  1. 山东省交通医院普外科
  • 出版日期:2014-12-03 发布日期:2015-01-20
  • 通讯作者: 王宏，Email： qingmeisu6856@163.com

Expressions and significances of sICAM-1 and sCD44v6 in peritoneal lavage fluid after laparoscopically assisted radical gastrectomy

  1.  Department of General Surgery, Shandong Province Traffic Hospital, Ji′nan 250031, China
  • Online:2014-12-03 Published:2015-01-20
  • Contact: Wang Hong, Email: qingmeisu6856@163.com

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摘要： 目的探讨腔镜胃癌手术腹腔冲洗液中可溶性细胞间黏附分子（sICAM1）、可溶性CD44变异体（sCD44v6）浓度的变化及意义，以此评价腔镜胃癌手术对腹膜种植转移的危险性。方法92例胃癌患者，按照随机数字表法分为对照组和试验组，对照组采用传统开腹手术，试验组采用腹腔镜手术，采用酶联免疫吸附法检测两组患者腹腔冲洗液中sICAM1、sCD44v6的浓度水平，并比较两组患者的肿瘤细胞阳性率。结果手术前对照组与试验组sICAM1、sCD44v6水平差异无统计学意义（t=0.198，P=0.543；t=0.897，P=0.429），手术后两者水平较手术前显著升高，但两组间比较差异无统计学意义（t=0.766，P=0.312；t=1.092，P=0.129）。结论腹腔镜胃癌根治术并不增加腹腔冲洗液中sICAM1、sCD44v6的表达，没有增加胃癌腹膜种植转移的危险性，值得临床进一步推广研究。

关键词: 胃肿瘤, 腹腔镜, 细胞黏附分子, 抗原, CD44

Abstract: ObjectiveTo explore the expressions and significances of sICAM1 and sCD44v6 in peritoneal lavage fluid after laparoscopically assisted radical gastrectomy, in order to evaluate the risk of laparoscopically assisted radical gastrectomy for the peritoneal plant transfer. MethodsNinetytwo patients with gastric cancer were randomly divided into the control group and the experimental group. The control group was treated with open laparotomy and the experimental group was treated with laparoscopic surgery. The concentrations of both sICAM1 and sCD44v6 were detected by enzyme linked immunosorbent assay. The positive rates of tumor cells in the two groups were compared. ResultsThe expressions of sICAM1, sCD44v6 in the two groups before operation had no significant difference （t=0.198, P=0.543; t=0.897, P=0.429）. After operation, sICAM1 and sCD44v6 levels increased significantly, but there was no significant difference between the two groups （t=0.766, P=0.312; t=1.092, P=0.129）. The positive rates of tumor cells in the two groups before and after operation have no significant differences (χ2＝0.789, P＝0.287; χ2＝0.912, P＝0.198). ConclusionLaparoscopically assisted radical gastrectomy does not increase the expression of sICAM1 and sCD44v6 in peritoneal lavage fluid and the risk of peritoneal metastasis. It is worthy of clinical popularization and application.

Key words: Stomach neoplasms, Laparoscopes, Cell adhesion molecules, Antigens, CD44