国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (8): 696-699.doi: 10.3760/cma.j.issn.1673-422X.2014.09.016

• 论著 • 上一篇    下一篇

β-catenin在胃腺癌原发灶和转移淋巴结的 表达及意义

杜天幸,杨继元,李龙,赵会传,陈廷煊,李军川   

  1. 434000 荆州，长江大学附属第一医院肿瘤科（杜天幸、杨继元、李龙），病理科（赵会传、陈廷煊、李军川）
  • 出版日期:2014-09-25 发布日期:2014-09-05
  • 通讯作者: 杨继元 E-mail:yangjiyuanchina@163.com

Expression and significance of β-catenin in gastric adenocarcinoma and  the metastasis of lymphnode

Du Tianxing, Yang Jiyuan, Li Long, Zhao Huichuan, Chen Tingxuan, Li Junchuan   

  1. Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou 434000, China
  • Online:2014-09-25 Published:2014-09-05
  • Contact: Yang Jiyuan E-mail:yangjiyuanchina@163.com

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摘要： 目的探索β-catenin在胃腺癌原发灶及转移淋巴结的表达情况，判断其是否与浸润程度相关及能否为胃癌浸润转移提供依据。方法免疫组织化学法对156例胃腺癌组织、40例对应转移淋巴结、12例正常胃黏膜组织进行β-catenin检测，分析β-catenin在胃腺癌及对应转移淋巴结的表达情况，明确β-catenin的表达与胃腺癌临床病理特征之间的关系，判断原发灶与转移淋巴结β-catenin表达有无差异性。结果β-catenin在正常胃组织细胞膜的阳性表达率为100.0%(12/12)，在胃腺癌组织细胞膜的表达率为29.5%（46/156），在转移淋巴结细胞膜的表达率为10.0%（4/40）。β-catenin阳性表达与患者的年龄(χ2=2.160，P=0.142)、性别(χ2=1.229，P=0.268)无关，与肿瘤浸润深度（χ2=4.032，P=0.045)、肿瘤分化程度（χ2=6.093，P=0.048)、肿瘤分期（χ2=4.591，P=0.032)、淋巴结转移（χ2=4.485，P=0.034)有关；β-catenin的异常表达或表达缺失在胃腺癌转移淋巴结的发生率高于原发灶组织（χ2=6.362，P=0.012)。结论βcatenin可帮助判断胃腺癌恶性程度、肿瘤侵袭转移能力等生物学行为。

关键词: 胃肿瘤, 肿瘤转移, 淋巴结, &beta, 连环素

Abstract: ObjectiveTo explore the expressions of βcatenin in gastric adenocarcinoma primary tumors and metastatic lymph nodes， and to determine if it is associated with infiltration degree and whether it can provide the basis for gastric cancer metastasis. MethodsThe expressions of βcatenin were detected in 156 patients with gastric adenocarcinoma specimens, 40 cases with the corresponding lymph nodes and 12 cases of normal gastric tissues by the method of immunohistochemistry.  The expressions of βcatenin in gastric adenocarcinoma and corresponding lymph node metastases were analysed. The relationship between the expression of βcatenin and the clinical pathological features of gastric adenocarcinoma was ascertained, and difference between them was observed. ResultsThe positive expression rate of βcatenin in normal gastric tissue membrane was 100.0%(12/12).  The expression rate of βcatenin was 29.5% (46/156) in adenocarcinoma cell membrane, and it was 10.0% (4/40) in metastatic lymph nodes cell membrane. The positive expression of βcatenin was not associated with patient′s age(χ2=2.160, P=0.142), gender (χ2=1.229, P=0.268), but it was associated with tumor infiltration degree (χ2=4.032, P=0.045), degree of tumor differentiation (χ2=6.093, P=0.048), tumor stage (χ2=4.591, P=0.032), and metastasis lymph nodes (χ2=4.485, P=0.034). The incidence of abnormal or loss expression of βcatenin in gastric adenocarcinoma metastatic lymph nodes was higer than that in gastric adenocarcinoma (χ2=6.362, P=0.012). ConclusionThe expression of βcatenin will be a great help to judge the biological behaviors such as the malignant degree of tumor and the capacity of tumor invasion and metastasis.

Key words: Stomach neoplasms, Neoplasm metastasis, Lymph nodes, Beta catenin