国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 456-459.

• 综述 • 上一篇    下一篇

胃癌预后分子标志物

李彩燕, 顾康生   

  1. 230022 合肥，安徽医科大学第一附属医院肿瘤内科
  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 顾康生，E-mail:gks63@tom.com E-mail:gks63@tom.com

Molecular markers for prognosis of gastric cancer

LI  Cai-Yan, GU  Kang-Sheng   

  1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: GU Kang-Sheng E-mail:gks63@tom.com

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摘要： 多种分子标志物与胃癌预后有关，如AT丰富结构域1A（ARID1A）基因的表达缺失、CD133和生存素的过表达均可致胃癌发生，且预后不良；瘦素、CD44、微小RNA（miRNA）则与胃癌侵袭转移密切相关；富含半胱氨酸的酸性分泌蛋白（SPARC)低表达有助于胃癌血管生成，但其表达与胃癌预后的相关性有待进一步研究；而核苷酸切除修复交叉互补基因1（ERCC1）在胃癌中的表达及其基因多态性则可能为用药选择提供依据。

关键词: 胃肿瘤, 生物学标记, 预后

Abstract: A variety of molecular markers are related to the prognosis of gastric cancer, such as the the loss expression of AT rich interactive domain 1A (ARID1A), the overexpression of CD133 and survivin are releated to the incidence and poor prognosis of gastric cancer; leptin, CD44 and microRNA (miRNA) are releated to the invasion and metastasis of gastric cancer; the low expression of secreted protein acidic and rich in cysteine (SPARC) contributes to the angiogenesis of gastric cancer, but the relationship between SPARC and prognosis needs further study; the expression and gene polymorphism of excision repair cross-complementing 1 (ERCC1) may be useful for choice of medication in the treatment of gastric cancer.

Key words: Stomach neoplasms, Biological markers, Prognosis