国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 449-452.

• 综述 • 上一篇    下一篇

微小RNA在乳腺癌耐药中的研究

王雪梅, 路丹   

  1. 150086 哈尔滨医科大学附属第二医院肿瘤内科
  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 路丹，E-mail:ludan1972@medmail.com.cn E-mail:ludan1972@medmail.com.cn
  • 基金资助:

    黑龙江省教育厅科学技术研究项目（12521245）

Progress of microRNAs in regulating drug resistance of breast cancer

WANG  Xue-Mei, LU  Dan   

  1. Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: LU Dan E-mail:ludan1972@medmail.com.cn

PDF

1274

摘要： 乳腺癌的多药耐药（MDR）是造成乳腺癌治疗失败的关键因素。微小RNA（miRNA）是一种内源性表达小分子单链RNA，通过与靶基因的信使RNA结合调控基因的转录后表达。miRNA参与了乳腺癌耐药形成的多种机制，是治疗耐药乳腺癌的可行靶点。寻找新的miRNA并研究其在乳腺癌耐药中的作用已成为当今研究的热点。

关键词: 微RNAs, 乳腺肿瘤, 抗药性

Abstract: Multi-drug resistance (MDR) of breast cancer is a key factor of breast cancer treatment failure. MicroRNA (miRNA) is a class of endogenous expressed, small, single-stranded RNA molecules, and regulate the expression of genes at post-transcriptional level by combining with target message RNA. MiRNA participate in the mechanisms of drug resistance of breast cancer, and are feasible therapeutic targets for the treatment of drug resistance in breast cancer. Finding and studying miRNA related with drug resistance of breast cancer as well as their mechanisms have become a current research hotspot.

Key words: MicroRNAs, Breast neoplasms, Drug resistance