国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 65-68.

• 综述 • 上一篇    下一篇

家族性胃癌研究进展

于俊秀, 李振方   

  1. 252000聊城市人民医院胃肠外科
  • 出版日期:2013-01-08 发布日期:2013-01-15

Research progress of familial gastric cancer

YU  Jun-Xiu, LI  Zhen-Fang   

  1. Department of Gastrointestinal Surgery, Liaocheng People’s Hospital, Liaocheng  252000, China
  • Online:2013-01-08 Published:2013-01-15

PDF

1655

被引次数

7

摘要： 家族性胃癌(FGC)成因包括E-钙黏蛋白（CDH1）基因突变、幽门螺杆菌感染等因素。FGC患者中位年龄50～65岁，男女性别比约2:1，肿瘤多位于远端胃，组织学类型以弥漫型多见。有胃癌家族史，特别是父母为胃癌者患胃癌风险增加。当前的技术手段较难早期发现FGC，预防FGC的方法包括根治幽门螺杆菌、预防性全胃切除术等。

关键词: 胃肿瘤, 家庭, 遗传

Abstract: The etiology of familial gastric cancer (FGC) are E-cadherin (CDH1) mutations, helicobacter pylori infection, etc. The median age of patients with FGC is 50—65 years old. The male-female sex ratio is 2:1. The most of tumors of FGC locate in distal stomach and present diffuse type in histological classification. It is reported that the people who has a family history of gastric cancer especially for those parents has an increased risk of gastric cancer. It is difficult to find FGC in early stage by current technology. The preventive methods include eradication of helicobacter pylori and prophylactic total gastrectomy, etc.

Key words: Stomach neoplasms, Family, Heredity