国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 848-850.

• 综述 • 上一篇    下一篇

EML4-ALK与非小细胞肺癌相关研究进展

王梦, 杨继元   

  1. 434100 荆州，长江大学附属第一医院肿瘤科

  • 出版日期:2012-11-08 发布日期:2012-11-16

EML4-ALK fusion gene in non-small cell lung cancer

WANG  Meng, YANG  Ji-Yuan   

  1. Department of Medical Oncology，the First Affiliated Hospital，Yangtze University ,Jingzhou 434100，China
  • Online:2012-11-08 Published:2012-11-16

PDF

1906

被引次数

6

摘要： EML4-ALK是新近发现的主要表达于非小细胞肺腺癌中的融合基因，多出现在年轻的轻度吸烟或非吸烟患者中, ALK抑制剂crizotinib治疗EML4-ALK阳性非小细胞肺癌有很高的应答率，其出现进一步完善了非小细胞肺癌的个体化治疗。

关键词: 癌, 非小细胞肺, 肺肿瘤, 肿瘤标记

Abstract: EML4-ALK fusion oncogene represents a new molecular target which appears mainly in lung adenocarcinoma. EML4-ALK is detected more frequently in young non-small-cell lung cancer patients who never or light smoke. ALK inhibitors（crizotinib）for the treatment of the EML4-ALK-positive non-small cell lung cancer has a high response rate. This finding can improve the individual treatment of non-small cell lung cancer.

Key words: Carcinoma, non-small-cell, Lung neoplasms, Tumor markers