国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (5): 359-362.

• 综述 • 上一篇    下一篇

多药耐药相关因子与肿瘤侵袭转移的相关性研究

黄子奇，卢列盛，丁卫星   

  1. 上海，同济大学附属第十人民医院胃肠外科
  • 出版日期:2012-05-08 发布日期:2012-05-02
  • 通讯作者: 丁卫星，E-mail: dwxing@medmail.com.cn E-mail:dwxing@medmail.com.cn

Drug resistance related factors and cancer metastasis

HUANG Zi-qi, LU Lie-sheng, DING Wei-xing.   

  1. Department of Gastrointestinal Surgery, Shanghai Tenth People′s Hospital, Shanghai Tongji University of Medicine, Shanghai 200072, China
  • Online:2012-05-08 Published:2012-05-02
  • Contact: DING Wei-xing, E-mail: dwxing@medmail.com.cn E-mail:dwxing@medmail.com.cn

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被引次数

2

摘要： 随着越来越多的多药耐药相关基因及细胞因子陆续发现，人们对肿瘤的细胞学侵袭转移机制有了更深入的理解，许多提示两者存在内在联系的证据也相继被发现。这些研究为进一步阐明两者之间的调控影响机制提供了新思路，揭示了其中的联系可能存在于细胞基因表达及转录水平，并存在着复杂多样的调控因素。通过深入研究肿瘤抗药性与侵袭转移的关系，相信将有助于更好地指导肿瘤的临床治疗

关键词: 抗药性, 肿瘤, 抗药性, 多药, 肿瘤侵润, 肿瘤转移

Abstract: As multidrug resistance related genes and cell factors are discovered one after another, people have a more thorough understanding to the oncological mechanisms of cancer metastasis. Many evidences of the inherent link between the two tips have been found. These researches provide new ideas to further clarify the regulation mechanisms between them. It is revealed that the inherent link maybe occur on the gene expression and transcription, and with complicated regulative factors. Indepth study of the relations between cancer multidrug resistance and metastasis will help to guide the clinical treatment of tumor.

Key words: Drug resistance, neoplasm, Drug resistance, multiple, Neoplasm invasiveness, Neoplasm metastasis