新型免疫检查点TIGIT在多发性骨髓瘤免疫治疗中的研究现状与应用前景

doi:10.3760/cma.j.cn371439-20221024-00025

国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (2): 122-125.doi: 10.3760/cma.j.cn371439-20221024-00025

新型免疫检查点TIGIT在多发性骨髓瘤免疫治疗中的研究现状与应用前景

张雨潇, 张连生(), 李莉娟()

兰州大学第二医院血液科，兰州 730000

收稿日期:2022-10-24 修回日期:2022-12-12 出版日期:2023-02-08 发布日期:2023-03-22
通讯作者: 张连生，Email：zhanglsh@lzu.edu.cn；李莉娟，Email：doctorjuan@sina.com
基金资助:
国家血液系统疾病临床医学研究中心委托课题(2021WWA01);兰州大学第二医院萃英科技创新项目(CY2017-ZD04);兰州大学第二医院萃英科技创新项目(CY2019-MS14)

Research status and application prospect of a novel immune checkpoint TIGIT in the immunotherapy of multiple myeloma

Zhang Yuxiao, Zhang Liansheng(), Li Lijuan()

Department of Hematology，Lanzhou University Second Hospital，Lanzhou 730000，China

Received:2022-10-24 Revised:2022-12-12 Online:2023-02-08 Published:2023-03-22
Contact: Zhang Liansheng，Email：zhanglsh@lzu.edu.cn；Li Lijuan，Email：doctorjuan@sina.com
Supported by:
National Clinical Medical Research Center for Hematological Diseases Subject of Commission(2021WWA01);Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2017-ZD04);Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2019-MS14)

摘要/Abstract

摘要：

T细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域（TIGIT）是近年新兴的免疫检查点蛋白，研究表明TIGIT能够使免疫细胞功能障碍，减弱抗肿瘤效应，导致肿瘤免疫耐受与免疫逃逸。通过阻断TIGIT可以逆转免疫细胞衰竭，发挥抗肿瘤效应，有望成为新一代多发性骨髓瘤治疗靶点。

关键词: 多发性骨髓瘤, 免疫治疗, TIGIT

Abstract:

T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain （TIGIT） is a new immune checkpoint protein. Studies have shown that TIGIT can cause dysfunction of immune cells，weaken the anti-tumor effect，thus leading to tumor immune tolerance and immune escape. Blocking TIGIT can reverse immune cell failure and exert anti-tumor effect，which is expected to become a new therapeutic target for multiple myeloma.

Key words: Multiple myeloma, Immunotherapy, TIGIT

张雨潇, 张连生, 李莉娟. 新型免疫检查点TIGIT在多发性骨髓瘤免疫治疗中的研究现状与应用前景[J]. 国际肿瘤学杂志, 2023, 50(2): 122-125.

Zhang Yuxiao, Zhang Liansheng, Li Lijuan. Research status and application prospect of a novel immune checkpoint TIGIT in the immunotherapy of multiple myeloma[J]. Journal of International Oncology, 2023, 50(2): 122-125.

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新型免疫检查点TIGIT在多发性骨髓瘤免疫治疗中的研究现状与应用前景

Research status and application prospect of a novel immune checkpoint TIGIT in the immunotherapy of multiple myeloma

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